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February 27th, 2009 at 6:30 pm
Phil – I can agree on some accounts, but drugs are like cars (glup), the first one is not always the best one. Mevacor to Zocor to Lipitor to Crestor – it is the same thing, just different potency at the target (or other targets in the case of Crestor). Not that we need that many choices, but there are distinct differences between the drugs – even for this class. Also, people respond differently to the same drug (e.g., anti-depressants (Prosac, Zoloft, Zyprexa), aspirin vs NSAID vs tylenol for pain relief, etc.). Biotech is acutally much more efficient at bringing the things to phase I/II, we just don’t have the capital to bring things to market (aka the safety thing). Once things make it through Phase IIb and work, most likely (80% or so the stats say), a drug should make it to market (unless you are Neurocrine of course, and screw up the clinical trials….morons and same goes for Pfizer for letting them run the trials). The statistics were 1:7000 researchers for biotech vs. 1:35000 for big pharma to bring things to market.
Again, biologics are a different beast. Humera and Remicade are different mAbs (monoclonal antibodies) to the same target (TNF). JnJ/Amgen/Roche are also the same for anemia. That is were COGs and competition can drive the price on the market.
While I am on the topic of drugs, much of the healthcare could be solved if they just legalized street drugs and taxed them like alcohol. LSD, ganja/mara/hash, heroine, uppers/downers etc…they are all over rated anyway…(I did not ingest any of these 😉 )