Posts Tagged ‘cancer’

Study: Cell Phones Cause Changes in Brain Activity

While this study doesn’t prove a positive link, it supports my worry that one may eventually be found between cell phone usage and brain cancer. – Ilene 

By ALICE PARK, courtesy of TIME 

HENRIK SORENSEN/GETTY IMAGES

Do cell phones cause cancer? We’d all like to know, but unfortunately there’s no clear answer — yet. Now an intriguing new study takes a first step toward a possible answer, suggesting that holding your cell phone to your ear does have a measurable effect on the brain, even during cell-phone sessions of less than an hour.

Dr. Nora Volkow, director of the National Institute on Drug Abuse (part of the National Institutes of Health), reports Tuesday in the Journal of the American Medical Association (JAMA) that a cell phone’s electromagnetic field can cause changes in brain activity. Specifically, she and her team found that the regions nearest to the antenna of closely held mobile devices showed higher rates of energy (or glucose) consumption.

Before you start to panic that all your cell-phone confessionals have set you up for some kind of brain tumor, remember this: higher rates of glucose metabolism in the brain can mean a number of things. Yes, tumor cells may gobble up more glucose to fuel their relentless growth, but healthy brain cells need constant replenishment too, to keep up the intricate network of messages and connections that help us think, eat, move and stay alive. Depending on what you’re doing, different areas of your brain will require more glucose — if you’re playing Scrabble, your language centers might demand more attention, while deep emotions such as grief or euphoria will cause neurons involved in the mood-regulating limbic system to consume more energy.

[...]

Researchers found that the brain regions closest to the active phone’s antenna showed the highest rates of glucose activity, and Volkow says the next step is to understand what that means. “Is this a temporary change that recovers every single time, or do chronic, long periods of exposure potentially have long-lasting effects? We need to know that,” she says.

The study is the first to look at glucose metabolism as a marker for the effect of a magnetic


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The Vitamin-D Debate: How Much is OK?

The Vitamin-D Debate: How Much is OK?

By Alice Park, courtesy of TIME 

 

Danny Kim for TIME

Spend a few minutes soaking up some rays and your body will start to pump out more vitamin D. Many health officials believe Americans are D-deficient, but in the age of sunblock and self-tanners, how many vitamin-D pills should we be popping? New guidelines for the optimal dietary dose are expected in the fall, and definitive studies on vitamin D’s effects on cancer, heart disease and cognition are ongoing. In the meantime, here’s where the science stands.

Cancer
Vitamin D may prevent cancer by suppressing the cell growth and blood-vessel formation that feed tumors. At least that’s the idea, based on animal studies and analyses of human cells. But trials in which patients take vitamin D have not shown a consistent lowering of cancer risk.

One four-year trial of 1,200 postmenopausal women found a 77% lower risk of all cancers among those taking calcium and 1,000 IU of vitamin D a day than among those taking a placebo. A larger study, however, in which subjects took 400 IU of vitamin D — in the absence of an official daily recommended intake, that’s the "adequate" intake for adults ages 51 to 70 — did not show lower breast-cancer risk.

The data are strongest for colorectal cancer: subjects with higher blood levels of vitamin D were half as likely as those with lower levels to develop the disease. 

Heart Disease
Studies on animals and human-cell cultures indicate that vitamin D has a protective effect on the heart, controlling the release of stress hormones that lead to high blood pressure and inflammation.

Studies on human subjects confirm this link. In one trial, men whose blood work showed D levels below 30 nanograms per milliliter — the amount the Institute of Medicine says adults should aim for — were twice as likely to have a heart…
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FREAK YOURSELF OUT WITH NEW AT-HOME GENETIC TESTING KIT

I’m not likely to ruin my life and take this test, but can see the value. For example, small amounts of alcohol, particularly red wine, may lower the risk of heart disease while simultaneously increasing the risk for certain cancers. If a genetic test revealed a higher than normal risk for heart disease, but not cancer, maybe a glass of wine would be more enjoyable than if the test revealed the opposite results. Knowing one’s risk areas might be of use in financial planning as well.  

Benefit or not, I hope the package includes a lot of disclaimers such as "we are not responsible for the effects of any food or drinking binges in celebration of your low risk test results."  - Ilene 

FREAK YOURSELF OUT WITH NEW AT-HOME GENETIC TESTING KIT

Courtesy of Richard Metzger of Dangerous Minds 

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Attention hypochondriacs! If you are feeling the need to seriously freak yourself out, look no further than your local Walgreens store! Yup, starting Friday you can purchase an at-home test kit that allows people who, well, worry about these things (obsessively) to see if their DNA makes them more likely to develop one (or more!) of dozens of different health conditions. Breast cancer? Check. Heart disease? Check! Alzheimer’s disease? Can do! Just swab your cheek, pop it in the mail and within a week or so, your life will be completely ruined!

From The Chicago Tribune:

The product’s introduction raises immediate concerns among scientists, bio-ethicists and genetic counselors. They worry that consumers will misuse or misunderstand the results of a test so open to interpretation it is potentially meaningless, or frightening, especially without a full medical assessment.

On Tuesday, the Food and Drug Administration told the Tribune it is investigating the medical claims the product’s manufacturer, California-based Pathway Genomics, is making in marketing its genetic test, which hasn’t been approved by U.S. regulators.

Pathway officials say the company’s home genetic test meets federal regulations and doesn’t require FDA approval. “The tests conducted are not an in-vitro medical device and are not intended for use in diagnosis, treatment, mitigation or cure of disease. It does provide information that allows a person to learn about their health to make healthier lifestyle choices,” said Ed MacBean, Pathway’s vice president of product management. “If the FDA contacts us, we will discuss it and address any concerns they


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Cell social network reveals rogue cancer switches

Cell social network reveals rogue cancer switches

guys from government sachsCourtesy of New Scientist 

IN CERTAIN social circles, it’s not what you know, but who you know that counts. The same seems to be true of the gene switches that turn on cancer cells.

One way cells turn genes on and off is via small RNA molecules. In cancer, the usual pattern of microRNA production is disrupted…

Carlo Croce,… created a diagram of interacting miRNAs for normal body cells by connecting them according to which genes they target and the function of those genes, in a way similar to analyses of human social networks. Most miRNAs have limited effects, but it turns out that a few extend their influence in many directions – just as a few people in a social network seem to "know everybody".

When the researchers compared these networks for ordinary cells and for cells from 51 forms of cancer, they found that all the miRNAs of ordinary cells were connected in a single network…

What’s more, the highly connected "hub" miRNAs were often different for cancer cells (Genome Research, DOI: 10.1101/gr.098046.109). These unique hubs might represent key points of attack in cancer therapies, says Croce.

Whole Cancer Network article here.>>

Social network analogy: The Guys from Government Sachs and pic credit, NY Times 


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High doses of antioxidant supplements induce stem cell genetic abnormalities

This is interesting, and important if you’re taking lots of supplements thinking that the more antioxidants you take, the longer you’ll live. Research is providing plenty of evidence that it doesn’t work so simply, while supplements fail to act according to the logical prevailing theory. Here’s another piece. – Ilene  

High doses of antioxidant supplements induce stem cell genetic abnormalities

Spoonful of dietary supplements

Courtesy of David Granovsky, in SCIENCE & STEM CELLS 

High doses of antioxidant supplements induce stem cell genetic abnormalities

High doses of antioxidant nutritional supplements, such as vitamins C and E, can increase genetic abnormalities in cells, which may predispose supplement-takers to developing cancer, according to a new study from the Cedars-Sinai Heart Institute.

The study, led by Eduardo Marbán, M.D., Ph.D., director of the Cedars-Sinai Heart Institute, was published online today in the medical journal Stem Cells. The study also will appear in the journal’s July printed edition.

Marbán and his team accidentally discovered the danger of excessive antioxidant doses while seeking a way to reduce the genetic abnormalities that occurred naturally when the scientists sought to multiply human cardiac stem cells.

Marbán stressed that the study’s finding applies only to excessive  and not to foods that are rich in antioxidants, such as milk, oranges, blueberries and peanuts. In recent years, multiple studies have touted the benefits of foods rich in antioxidants.

“Taking one multivitamin daily is fine, but a lot of people take way too much because they think if a little is good, a lot must be better,” said Marbán, who is also the Mark Siegel Family Professor at Cedars-Sinai. “That is just not the case. If you are taking 10 or 100 times the amount in a daily multivitamin, you may be predisposing your cells to developing cancer, therefore doing yourself more harm than good.”

In laboratories, stem cells are often grown in a Petri dish culture than is composed of 20 percent oxygen, whereas cells growing inside human tissue are exposed to just 3 to 5 percent oxygen. But Marbán’s team of researchers became frustrated because the higher concentration of oxygen in lab-grown stem cells resulted in 9 percent of the cells being rejected because of genetic abnormalities.

“We sought to counter that oxidation problem by adding high doses of antioxidants directly to
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Court rules against patenting human genes

Not having read the 152 page decision, I’m still happy with the outcome--if DNA is not patentable, then the argument that the "process of isolating genes makes them patentable" makes no sense. – Ilene 

Court rules against patenting human genes

By TIFFANY O’CALLAGHAN, Courtesy of TIME 

© Michael Rosenfeld/Science Faction/Corbis

In a decision that could have broad ramifications for future genetic research and medical practice, United States District Court Judge Robert W. Sweet ruled Monday that patents on two genes linked to ovarian and breast cancer, BRCA-1 and BRCA-2, were invalid. The case brought by a group including the American Civil Liberties Union, the Public Patent Foundation at the Benjamin N. Cardozo School of Law in New York and several medical institutions and individual patients, argued that, because genes are products of nature, they cannot be patented, The New York Times reports. Sweet ultimately agreed with this argument, dismissing claims from Myriad Genetics, which holds the contested gene patents, that the process of isolating genes makes them patentable. (Drawing on a 1980 Supreme Court decision in favor of patents on living organisms, many expected the federal judge to rule in favor of the patent holder, the New York Times reports.) Yet, ultimately, Sweet found the patents to be in violation of a "law of nature," and openly condemned the argument that gene isolation should influence patentability, calling it "“a ‘lawyer’s trick’ that circumvents the prohibition on the direct patenting of the DNA in our bodies but which, in practice, reaches the same result.”

The ruling from the U.S. Court for the Southern District of New York state, has two major implications. First, if it withstands appeal, "it should greatly widen access to BRCA testing in the US, where Myriad’s patent has inflated the cost," according to the Times of London. Currently, women have to pay Myriad Genetics some $3,000 in order to get tested for BRCA-1 or BRCA-2, NPR reports. In Europe, where patents on the two genes are either limited or shared with cancer research organizations, there is already wider access to the tests, according…
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Cancer Fears Plague America’s Shale Gas Revolution

Cancer Fears Plague America’s Shale Gas Revolution

Courtesy of Vincent Fernando at Clusterstock/Business Insider

Shale Gas Basins USA

 

While drilling techniques for natural gas from American shale formations continue to appear safe overall, many are questioning the reliability and objectivity of current environmental assessments.

Statements such as the following only cause confusion and distrust:

Dallas News: Nearly one-fourth of the sites monitored in North Texas’ Barnett Shale natural-gas region had levels of cancer-causing benzene in the air that could raise health concerns, state regulators said Wednesday.

They emphasized, however, that gas companies have fixed the worst emission problems and are working on less-serious sites where the state still wants benzene levels to come down.

"We don’t have a widespread air-quality issue, at least according to the data," said John Sadlier, the Texas Commission on Environmental Quality’s deputy director for compliance and enforcement.

Mayor Calvin Tillman of the tiny Denton County town of Dish criticized the study for not including enough tests in residential areas or enough long-term sampling. The town commissioned its own monitoring last year that found extremely high benzene levels.

Surging Oil Industry Brings Opportunity To Rural California

"I don’t think they want to find anything in a populated area, and I think their sampling reflects that," Tillman said.

The shale gas drilling (and frakking) safety tests of today will have huge ramifications for tomorrow, given that current drilling only scratches the surface of the U.S.’s potential shale-derived natural gas reserves.

Still, given the major commitments in American shale gas made by Exxon (via its recent XTO acquisition) and France’s Total (via its Chesapeake tie-up), it seems highly likely that shale’s environmental concerns will eventually be managed. In the end there’s likely a way to extract the gas safely without too much added cost, if it already isn’t safe enough. Note Total just closed its $2.25 billion Chesapeake joint-venture deal. Regardless, Chesapeake shares are falling.

The author owns shares in Chesapeake Energy (CHK).

 


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Orphan Drugs Are Good! BioMarin Pharmaceuticals

Orphan Drugs Are Good! BioMarin Pharmaceuticals

Courtesy of Pharmboy

Sick child visited at

A rare disease, sometimes known as an orphan disease, is any disease that is not common. Typically, a rare disease has such a low prevalence in a population that a physician in a busy general practice would not expect to see more than one case a year. Most rare diseases are genetic--present throughout the person’s entire life, even if symptoms do not appear immediately. However, many rare diseases appear early in life, and about 30% of children with rare diseases die before reaching their fifth birthdays.

No single cutoff number has been agreed upon for which a disease is considered rare. A disease may be considered rare in one part of the world, or in a particular group of people, but still be common in another. In the United States of America, the Rare Disease Act of 2002 defines rare disease strictly according to prevalence, as any disease or condition that affects less than 200,000 persons in the United States, or about 1 in 1,500 people.

BioMarin’s (BMRN) core business and research is in enzyme replacement therapies for orphan diseases. They are the first company to provide therapeutics for mucopolysaccharidosis type I (MPS I), by manufacturing Aldurazyme (commercialized by Genzyme Corporation). BioMarin is also the first company to provide therapeutics for Phenylketonuria (PKU)

As of 2005, BioMarin commercialized arylsulfatase B (Naglazyme) as an enzyme replacement therapy for the treatment of mucopolysaccharidosis VI (MPS VI), and in 2007 a drug version of tetrahydrobiopterin (Kuvan), the first medication-based intervention to treat phenylketonuria.

On 11/30/09, BioMarin announced that the FDA has granted orphan drug designation for 3,4-diaminopyridine (3,4-DAP), amifampridine phosphate, for the rare autoimmune disease Lambert Eaton Myasthenic Syndrome (LEMS). 3,4-DAP has previously received orphan drug designation in the E.U. Also, in October 2009, the Committee for Medicinal Products for Human Use of the European Medicines Evaluations Agency adopted a positive opinion recommending approval of amifampridine phosphate for LEMS. If approved by the European Commission, amifampridine phosphate will be the first approved treatment for LEMS, thereby conferring orphan drug protection and providing ten years of market exclusivity in Europe. BMRN expects to meet with the FDA in early 2010 to determine the necessary regulatory path for
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Zero Hedge

Tumbling Futures Rebound After Varoufakis Resignation; Most China Stocks Drop Despite Massive Intervention

Courtesy of ZeroHedge. View original post here.

Submitted by Tyler Durden.

More than even the unfolding "chaos theory" pandemonium in Greece, market watchers were even more focused on whether or not China and the PBOC will succeed in rescuing its market from what is now a crash that threatens social stability in the world's most populous nation. And, at the open it did. The problem is that as the trading session progressed, the initial 8% surge in stocks faded as every bout of buying was roundly sold into until every other index but the benchmark Shanghai Composite turned sharply red.

The reason the SHCOMP stayed above water is because China's sovereign fund Huijin was in the market to keep large caps like PetroChina, ICBC up. And then, s...



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Phil's Favorites

Shades of Roosevelt: Greece Safety Box Controls; Cash in Hand is King

Courtesy of Mish.

Back in January, I warned Greek citizens to take money out of Greek banks. I also warned not put it in safe deposit boxes. Both comments were dead-on accurate.

Greece Safety Box Controls

Please consider Greeks Cannot Tap Cash in Safe Deposit Boxes Under Capital Controls.
Greeks cannot withdraw cash left in safe deposit boxes at Greek banks as long as capital restrictions remain in place, a deputy finance minister told Greek television on Sunday.

Greece's government shut banks and imposed capital controls a week ago to prevent the country's banks from collapsing under the weight of mass withdrawals.

Deputy Finance Minister Nadia Valavani told Alpha TV that, as part of those measures, the go...



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Market News

The Big Fat Greek 'No'

The Greeks said 'NO.' 61% voted against accepting the latest bailout package offered to them by their European creditors. Here's a tour of the many thoughts about what's next for Greece.  

[Picture Source: Drudge Report Headline]

Greece Says 'NO'; Thousands Celebrate; Emergency Summit Called (Business Insider)

The landslide victory for the "No" campaign is a major surprise. Athens exploded in celebration over the result, with thousands streaming into Syntagma Square, waving Greek flags, chanting, and setting off fire...



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Digital Currencies

Bitcoin Surges After Initial Forecasts Show "No" Vote Ahead

Courtesy of ZeroHedge. View original post here.

Submitted by Tyler Durden.

If the early bitcoin markets are an indication of what will happen once New Zealand opens for illiquid FX trade, it will be a risk off kinda day.

And that doesn't even take into account the pandemonium that will be unleashed in China in a few hours after the PBOC just went all-in to halt the crashing stock market. What if it fails to get a green close before tomorrow's US open?

Source: ...



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Insider Scoop

Russian Inflation Expected To Continue To Fall

Courtesy of Benzinga.

Related RSX Russia's Gazprom Reportedly Shuts Off Gas Delivery To Ukraine ETF Investors Aren't Afraid Of Greek Default Snake Oil Stats (Seeking Alpha)

In a report published Friday, Barclays analyst Daniel Hewitt explained that the infl...



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Chart School

Chinese SSEC rally with Wyckoff Logic

Courtesy of Read the Ticker.

Supply and demand is the leading force within stock prices, you must know the tea leaves. Richard Wyckoff logic is the only known method of understanding supply and demand with the stock market.Readtheticker.com provides all the tools you need to be a Wyckoff master analyst.More from RTT Tv

NOTE: readtheticker.com does allow users to load objects and text on charts, however some annotations are by a free third party ima...

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All About Trends

Mid-Day Update

Reminder: David is available to chat with Members, comments are found below each post.

Click here for the full report.




To learn more, sign up for David's free newsletter and receive the free report from All About Trends - "How To Outperform 90% Of Wall Street With Just $500 A Week." Tell David PSW sent you. - Ilene...

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Kimble Charting Solutions

Shanghai index creates historic reversal pattern like 2007

Courtesy of Chris Kimble.

CLICK ON CHART TO ENLARGE

Much of the attention around the world seems to be revolving around a small country called Greece. What about the most populated country in the world (China), any key messages coming from there of late?

Well another Month, Quarter and Half a year are in the books. With this in mind I wanted to look at Monthly action of the hottest stock market in the world, the Shanghai Index. Above looks at the Shanghai index over the past 25-years. The 100%+ rally over the past year has pushed the Shanghai index up to its 23% Fibonacci ratio and a long-term resistance line, that has been in play for 25-years at (1) above.

As the Shanghai index was hitting this...



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OpTrader

Swing trading portfolio - week of June 29th., 2015

Reminder: OpTrader is available to chat with Members, comments are found below each post.

 

This post is for all our live virtual trade ideas and daily comments. Please click on "comments" below to follow our live discussion. All of our current  trades are listed in the spreadsheet below, with entry price (1/2 in and All in), and exit prices (1/3 out, 2/3 out, and All out).

We also indicate our stop, which is most of the time the "5 day moving average". All trades, unless indicated, are front-month ATM options. 

Please feel free to participate in the discussion and ask any questions you might have about this virtual portfolio, by clicking on the "comments" link right below.

To learn more about the swing trading virtual portfolio (strategy, performance, FAQ, etc.), please click here ...



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Sabrient

Sector Detector: Bulls under the gun to muster troops, while bears lie in wait

Reminder: Sabrient is available to chat with Members, comments are found below each post.

Courtesy of Sabrient Systems and Gradient Analytics

Two weeks ago, bulls seemed ready to push stocks higher as long-standing support reliably kicked in. But with just one full week to go before the Independence Day holiday week arrives, we will see if bulls can muster some reinforcements and make another run at the May highs. Small caps and NASDAQ are already there, but it is questionable whether those segments can drag along the broader market. To be sure, there is plenty of potential fuel floating around in the form of a friendly Fed and abundant global liquidity seeking the safety and strength of US stocks and bonds. While the technical picture has glimmers of strength, summer bears lie in wait.

In this weekly ...



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Pharmboy

Baxter's Spinoff

Reminder: Pharmboy and Ilene are available to chat with Members, comments are found below each post.

Baxter Int. (BAX) is splitting off its BioSciences division into a new company called Baxalta. Shares of Baxalta will be given as a tax-free dividend, in the ratio of one to one, to BAX holders on record on June 17, 2015. That means, if you want to receive the Baxalta dividend, you need to buy the stock this week (on or before June 12).

The Baxalta Spinoff

By Ilene with Trevor of Lowenthal Capital Partners and Paul Price

In its recent filing with the SEC, Baxter provides:

“This information statement is being ...



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Mapping The Market

An update on oil proxies

Courtesy of Jean-Luc Saillard

Back in December, I wrote a post on my blog where I compared the performances of various ETFs related to the oil industry. I was looking for the best possible proxy to match the moves of oil prices if you didn't want to play with futures. At the time, I concluded that for medium term trades, USO and the leveraged ETFs UCO and SCO were the most promising. Longer term, broader ETFs like OIH and XLE might make better investment if oil prices do recover to more profitable prices since ETF linked to futures like USO, UCO and SCO do suffer from decay. It also seemed that DIG and DUG could be promising if OIH could recover as it should with the price of oil, but that they don't make a good proxy for the price of oil itself. 

Since...



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Promotions

Watch the Phil Davis Special on Money Talk on BNN TV!

Kim Parlee interviews Phil on Money Talk. Be sure to watch the replays if you missed the show live on Wednesday night (it was recorded on Monday). As usual, Phil provides an excellent program packed with macro analysis, important lessons and trading ideas. ~ Ilene

 

The replay is now available on BNN's website. For the three part series, click on the links below. 

Part 1 is here (discussing the macro outlook for the markets) Part 2 is here. (discussing our main trading strategies) Part 3 is here. (reviewing our pick of th...

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Help One Of Our Own PSW Members

"Hello PSW Members –

This is a non-trading topic, but I wanted to post it during trading hours so as many eyes can see it as possible.  Feel free to contact me directly at jennifersurovy@yahoo.com with any questions.

Last fall there was some discussion on the PSW board regarding setting up a YouCaring donation page for a PSW member, Shadowfax. Since then, we have been looking into ways to help get him additional medical services and to pay down his medical debts.  After following those leads, we are ready to move ahead with the YouCaring site. (Link is posted below.)  Any help you can give will be greatly appreciated; not only to help aid in his medical bill debt, but to also show what a great community this group is.

http://www.youcaring.com/medical-fundraiser/help-get-shadowfax-out-from-the-darkness-of-medical-bills-/126743

Thank you for you time!




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Philip R. Davis is a founder Phil's Stock World, a stock and options trading site that teaches the art of options trading to newcomers and devises advanced strategies for expert traders...

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Ilene is editor and affiliate program coordinator for PSW. She manages the site market shadows, archives, more. Contact Ilene to learn about our affiliate and content sharing programs.

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