Posts Tagged ‘genetic markers’

Genetic Test Improves Weight Loss Success With Diets

This is an interesting press release from Interleukin Genetics (ILI) about a genetic test that may allow people to better match their diet to their genetics.  I admit to a bit of skepticism, but here goes: first background information about the test from Interleukin Genetics’s website, and second, the press release. – Ilene 

Weight Management Test 

Human obesity arises from the interactions of multiple genes, environmental factors and behaviors, rendering management and prevention of obesity very challenging.  According to WHO, lack in physical activity and easy availability of palatable foods are the principle modified characteristic of our modern lifestyle that has contributed a lot to the observed obesity worldwide. Despite the fact that we are all exposed to the same environment, not everyone becomes obese.  This could be attributed to individual genetic differences.  Genetics determines an individual’s susceptibility to obesity when exposed to an unfavorable environment as well as the way he/she can respond to diet and exercise. There have been multiple reports that describe the heritability of obesity and also utilize genetic association studies to identify the gene-gene, gene environment and gene-diet interactions involved in the development of obesity. These studies have identified a certain number of single nucleotide polymorphisms (SNPs) that respond to diet and/or exercise.  For example, some SNPs make some people more sensitive to the amount of fat in the diet, while others make some people more resistant to exercise-induced weight loss.

Interleukin Genetics has developed a genetic test panel in the area of Weight Management (WM), which includes the genes that have been validated as significant modifiers of body weight and responsiveness to diet and exercise.  The genes were selected from the Obesity Gene Map Database based on a comprehensive review of the existing scientific literature using very stringent selection criteria by a team of experts from genetics, nutrition, obesity and weight management areas. 

The following process was used to develop the Weight Management genetic test panel:

  1. Dr. Louis Perusse, one of the authors of the Obesity Gene Map review (4), provided a list of all genetic variations that were associated with body weight, body mass index, or body fat and had been replicated in at least three clinical studies. Out of hundreds of genes reported in the scientific literature relative to obesity, only 16 met this first criterion.
  2. A team of experts then reviewed all evidence on the 16 gene variations


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Scientists Move Closer to Understanding Why We Age

Scientists Move Closer to Understanding Why We Age

By Eben Harrell / London, courtesy of TIME 

Time waits for no man, the old truism goes, but in recent years scientists have shown that it does seem to move more slowly for some. Molecular biologists have observed that people’s cells often age at different rates, leading them to make a distinction between "chronological" and "biological age."

But the reason for the difference remains only vaguely understood. Environmental factors such as smoking, stress and regular exercise all seem to influence the rate at which our cells age. Now, for the first time, researchers have found a genetic link to cellular aging — a finding that suggests new treatments for a variety of age-related diseases and cancers. 

The field of "biological aging" has in recent years focused on the long molecules of DNA contained in human cells called chromosomes. All chromosomes have protective caps at either end called telomeres. Each time a cell replicates itself (as it does before it dies), the telomeres shorten, like plastic tips fraying on the end of shoelace. Shortened telomeres have been linked to a host of age-related illnesses such as heart disease and certain cancers. (Scientists have yet to study whether telomeres influence a person’s appearance). Last year’s Nobel prize in medicine was awarded to three American scientists for their work in the field, and many scientists now believe telomeres are the closest we may come to identifying a biological clock — and our best bet for one day learning how to stop or turn back that clock. 

To better understand the aging discrepancy, a team of researchers in Britain and The Netherlands scanned more than 500,000 genetic variations across the human genome. Using a population of nearly 12,000, they then attempted to pinpoint a genetic link to telomere length. (See how to prevent illness at any age.) 

In a significant breakthrough, the team successfully identified that a particular gene sequence was associated with differences in telomere length between individuals. What’s more, the sequence was clustered near a gene called TERC, which is already known to play a role in the production of an enzyme called telomerase. Telomerase repairs telomeres when they shorten. "That was very exciting for us," says Professor Nilesh Samani, a cardiologist at the University of Leicester who co-led the research, published last week in Nature Genetics. "It gave us great…
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Zero Hedge

Coronavirus Kills Man In Shanghai As China Confirms Nearly 2,000 Cases

Courtesy of ZeroHedge View original post here.

Summary
  • First nCoV death reported in Shanghai
  • South Korea confirms third case
  • Toronto health officials to announce first 'presumptive case' of coronavirus in Canada
  • 1975 Cases Worldwide; 56 deaths (still about a 3% mortality rate)
  • 18 Chinese cities - 56 million people - quarantined
  • President Xi said China faces a 'grave situation' as the spread is 'accelerating'
  • US and Russia plan...


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Phil's Favorites

Preparing For Lower Returns

 

Preparing For Lower Returns

Courtesy of 

We’ve been hearing about the prospect of lower future returns for U.S. based investors for years now*. The thesis behind this is fairly straightforward; high recent returns coupled with high valuations in the stock market, and low interest rates in the bond market is not conducive to further above average returns.

Consider the following:

  • A U.S. only 60/40 portfolio has compounded at 10.5% over the last 10 years.
  • The CAPE ratio is at 30.9
  • The ten-year treasury is currently yielding 1.8%

...



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Chart School

Top Patterns for Retail Investors

Courtesy of Read the Ticker

Retail investors are last in line for market leading research, no matter, the retail investor can profit from these secret sauce patterns..

Well not so secret now, the main point is you do not have to climb Mount Everest to be called a mountain climber, there are many other hills to climb to make your mark. Just like stocks.

You do not have to battle with the high frequency traders to win in the markets, there are long and slow methods to do just as well.  

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Some charts from the video


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The Technical Traders

The Wuhan Wipeout - Could It Happen?

Courtesy of Technical Traders

News is traveling fast about the Corona Virus that originated in Wuhan, China. Two new confirmed cases in the US, one in Europe and hundreds in China. As we learn more about thispotential pandemic outbreak, we are learning that China did very little to contain this problem from the start. Now, quarantining two cities and trying to control the potential
outbreak, may become a futile effort.

In most of Asia, the Chinese New Year is already in full swing.  Hong Kong, China, Singapore, Malaysia, India and a host of other countries are already starting to celebrate the 7 to 10 day long New Year.  Millions of people have already traveled hundreds of thousands of miles to visit family...



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Kimble Charting Solutions

Bad News For Crude Oil Should Come From This Pattern, Says Joe Friday

Courtesy of Chris Kimble

It’s a good idea for investors to be aware of key indicators and inter-market relationships.

Perhaps it’s watching the US Dollar as an indicator for precious metals or emerging markets. Or watching interest rates for the economy. Experience, history, and relationships matter. And it’s good to simply add these to our tool-kit.

Today, we look at another relationship that has signaled numerous stock market tops and bottoms over the years, and especially the past several months, Crude Oil.

When crude oil tops or bottoms, it seems that ...



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Insider Scoop

5 Software-Application Stocks Moving In Thursday's After-Market Session

Courtesy of Benzinga

Gainers

Atlassian Corporation, Inc. (NASDAQ:TEAM) stock surged 9.7% to $145.50 during Thursday's after-market session. According to the most recent rating by Morgan Stanley, on January 13, the current rating is at Overweight.

Diebold Nixdorf, Inc. (NYSE:DBD) shares increased by 8.1% to $11.48. The most recent rating by DA Davidson, on December 13, is at Buy, with a price target of $17.00.

Telaria, Inc. (NYSE:TLRA) stock rose 4...



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Biotech

Snakes could be the original source of the new coronavirus outbreak in China

Reminder: We are available to chat with Members, comments are found below each post.

 

Snakes could be the original source of the new coronavirus outbreak in China

Chinese cobra (Naja atra) with hood spread. Briston/Wikimedia, CC BY-SA

Haitao Guo, University of Pittsburgh; Guangxiang “George” Luo, Univers...



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Members' Corner

The War on All Fact People

 

David Brin shares an excerpt from his new book on the relentless war against democracy and how we can fight back. You can also read the first, second and final chapters of Polemical Judo at David's blog Contrary Brin.

The War on All Fact People 

Excerpted from David Brin's new book, the beginning of chapter 5, Polemical Judo: Memes...



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Lee's Free Thinking

Why Blaming the Repo Market is Like Blaming the Australian Bush Fires

 

Why Blaming the Repo Market is Like Blaming the Australian Bush Fires

Courtesy of  

The repo market problem isn’t the problem. It’s a sideshow, a diversion, and a joke. It’s a symptom of the problem.

Today, I got a note from Liquidity Trader subscriber David, a professional investor, and it got me to thinking. Here’s what David wrote:

Lee,

The ‘experts’ I hear from keep saying that once 300B more in reserves have ...



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Digital Currencies

Cryptos Have Surged Since Soleimani Death, Bitcoin Tops $8,000

Courtesy of ZeroHedge View original post here.

Bitcoin is up over 15% since the assassination of Iran General Soleimani...

Source: Bloomberg

...topping $8,000 for the first time since before Thanksgiving...

Source: Bloomberg

Testing its key 100-day moving-average for the first time since October...

...



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Mapping The Market

How IPOs Are Priced

Via Jean Luc 

Funny but probably true:

...

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Promotions

Free eBook - "My Top Strategies for 2017"

 

 

Here's a free ebook for you to check out! 

Phil has a chapter in a newly-released eBook that we think you’ll enjoy.

In My Top Strategies for 2017, Phil's chapter is Secret Santa’s Inflation Hedges for 2017.

This chapter isn’t about risk or leverage. Phil present a few smart, practical ideas you can use as a hedge against inflation as well as hedging strategies designed to assist you in staying ahead of the markets.

Some other great content in this free eBook includes:

 

·       How 2017 Will Affect Oil, the US Dollar and the European Union

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Philip R. Davis is a founder Phil's Stock World, a stock and options trading site that teaches the art of options trading to newcomers and devises advanced strategies for expert traders...

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About Ilene:

Ilene is editor and affiliate program coordinator for PSW. She manages the site market shadows, archives, more. Contact Ilene to learn about our affiliate and content sharing programs.

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