Posts Tagged ‘genetic markers’

Genetic Test Improves Weight Loss Success With Diets

This is an interesting press release from Interleukin Genetics (ILI) about a genetic test that may allow people to better match their diet to their genetics.  I admit to a bit of skepticism, but here goes: first background information about the test from Interleukin Genetics’s website, and second, the press release. – Ilene 

Weight Management Test 

Human obesity arises from the interactions of multiple genes, environmental factors and behaviors, rendering management and prevention of obesity very challenging.  According to WHO, lack in physical activity and easy availability of palatable foods are the principle modified characteristic of our modern lifestyle that has contributed a lot to the observed obesity worldwide. Despite the fact that we are all exposed to the same environment, not everyone becomes obese.  This could be attributed to individual genetic differences.  Genetics determines an individual’s susceptibility to obesity when exposed to an unfavorable environment as well as the way he/she can respond to diet and exercise. There have been multiple reports that describe the heritability of obesity and also utilize genetic association studies to identify the gene-gene, gene environment and gene-diet interactions involved in the development of obesity. These studies have identified a certain number of single nucleotide polymorphisms (SNPs) that respond to diet and/or exercise.  For example, some SNPs make some people more sensitive to the amount of fat in the diet, while others make some people more resistant to exercise-induced weight loss.

Interleukin Genetics has developed a genetic test panel in the area of Weight Management (WM), which includes the genes that have been validated as significant modifiers of body weight and responsiveness to diet and exercise.  The genes were selected from the Obesity Gene Map Database based on a comprehensive review of the existing scientific literature using very stringent selection criteria by a team of experts from genetics, nutrition, obesity and weight management areas. 

The following process was used to develop the Weight Management genetic test panel:

  1. Dr. Louis Perusse, one of the authors of the Obesity Gene Map review (4), provided a list of all genetic variations that were associated with body weight, body mass index, or body fat and had been replicated in at least three clinical studies. Out of hundreds of genes reported in the scientific literature relative to obesity, only 16 met this first criterion.
  2. A team of experts then reviewed all evidence on the 16 gene variations


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Scientists Move Closer to Understanding Why We Age

Scientists Move Closer to Understanding Why We Age

By Eben Harrell / London, courtesy of TIME 

Time waits for no man, the old truism goes, but in recent years scientists have shown that it does seem to move more slowly for some. Molecular biologists have observed that people’s cells often age at different rates, leading them to make a distinction between "chronological" and "biological age."

But the reason for the difference remains only vaguely understood. Environmental factors such as smoking, stress and regular exercise all seem to influence the rate at which our cells age. Now, for the first time, researchers have found a genetic link to cellular aging — a finding that suggests new treatments for a variety of age-related diseases and cancers. 

The field of "biological aging" has in recent years focused on the long molecules of DNA contained in human cells called chromosomes. All chromosomes have protective caps at either end called telomeres. Each time a cell replicates itself (as it does before it dies), the telomeres shorten, like plastic tips fraying on the end of shoelace. Shortened telomeres have been linked to a host of age-related illnesses such as heart disease and certain cancers. (Scientists have yet to study whether telomeres influence a person’s appearance). Last year’s Nobel prize in medicine was awarded to three American scientists for their work in the field, and many scientists now believe telomeres are the closest we may come to identifying a biological clock — and our best bet for one day learning how to stop or turn back that clock. 

To better understand the aging discrepancy, a team of researchers in Britain and The Netherlands scanned more than 500,000 genetic variations across the human genome. Using a population of nearly 12,000, they then attempted to pinpoint a genetic link to telomere length. (See how to prevent illness at any age.) 

In a significant breakthrough, the team successfully identified that a particular gene sequence was associated with differences in telomere length between individuals. What’s more, the sequence was clustered near a gene called TERC, which is already known to play a role in the production of an enzyme called telomerase. Telomerase repairs telomeres when they shorten. "That was very exciting for us," says Professor Nilesh Samani, a cardiologist at the University of Leicester who co-led the research, published last week in Nature Genetics. "It gave us great…
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Phil's Favorites

This Time It's Different: Maybe? ...John Street Capital Joins Me On Panic With Friends

 

This Time It’s Different: Maybe? …John Street Capital Joins Me On Panic With Friends

Courtesy of Howard Lindzon

(Originally posted on July 10, 2020)

This made me laugh yesterday…

In the shoulda, coulda, woulda department today…a $500,000 investment in the Amazon IPO would be worth $1 billion today if you held it.

Onwards&helli...



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Biotech/COVID-19

How deadly is COVID-19? A biostatistician explores the question

 

How deadly is COVID-19? A biostatistician explores the question

The number of confirmed and probable deaths from COVID-19 in New York City was 23,247 as of July 10, which is more than eight times the number who died in the 9/11 attack. Angela Weiss / AFP via Getty Images

Courtesy of Ron Fricker, Virginia Tech

The latest statistics, as of July 10, show COVID-19-related deaths in U.S. are just under 1,000 per day nationally, which is down from a peak averag...



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Zero Hedge

Taleb: Tail-Risk Hedges Are Now A Necessity

Courtesy of ZeroHedge View original post here.

Authored by Michelle Jones via ValueWalk.com,

Tail risk hedges are designed to only pay off when the markets suddenly plunge, so many investors don’t have the stomach to carry them. However, one expert on tail risk funds advises investors not to be in the market right now if they aren’t using a tail hedge.

No V-shaped recov...

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Digital Currencies

Chainlink Crypto Surges To A New All-Time High - Here's Why...

Courtesy of ZeroHedge View original post here.

Authored by Joseph Young via CoinTelegraph.com,

Surging volume, price discovery, and new partnerships pushed Chainlink price to a new all-time high at $8.48...

image courtesy of CoinTelegraph

...

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The Technical Traders

Gold & Silver Measured Moves

Courtesy of Technical Traders

The next few weeks are certain to attract much attention to precious metals.  Hardly anyone can argue that Gold has not experienced an incredible upside price rally over the last 12+ months.  Recently, Gold closed above $1800 for the first time since 2011.  Our researchers believe the next target is $1935.  Keep reading to learn why we believe this is the next major price target for Gold.

Gold Weekly Price Analysis

Over the past 18+ months, Gold continues to develop price patterns that seem to be replicating going forward.  This pattern consists of an advance in price followed by consolidation/rotation in price to set up a new momentum base.  The example of this price advance ...



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ValueWalk

How Banks Can Mitigate Credit Losses

By David Donovan. Originally published at ValueWalk.

Without question, the economic impact caused by COVID-19 has rocked companies and consumers across the globe. Big companies are drawing heavily on credit lines. Mom and pop shops are struggling to stay afloat, despite the government funding small business loans to the tune of $659 billion, of which $130 billion is still unclaimed. Companies are now trying to figure out how they can proactively address high risk borrowers to avoid massive defaults that will inevitably putting banks in an even stickier predicament.

Q2 2020 hedge fund letters, conferences and more

With more than 40% of the econo...



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Kimble Charting Solutions

Commodity Index Price Reversal Raises Hope for "Double Bottom"

Courtesy of Chris Kimble

It’s been a rough decade for commodities… but there may be light at the end of the tunnel.

As you can see in today’s chart, the Equal Weight Commodity Index made new decade lows this spring at (1).

In general, this is bearish. BUT, prices reversed higher with a little attitude. Precious metals has been strong and crude oil is well off its lows.

This has given life to a potential double bottom pattern, as this year’s lows came in and around the 2009 financial crisis lows.

Is it possible that Commodities have created a long-term double bottom at (1)? Poss...



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Chart School

Dow 2020 Crash Watch - Update

Courtesy of Read the Ticker

Like 1929 the markets have bounced. This time it is on the back of the FED $6.5T money printing.

Previous Post: Dow 2020 Crash Watch 

But can the FED blow $6T every time the market rolls down to test support.

Yes, maybe before the US 2020 elections the FED will do 'what it takes'. But post elections not so much, the year 2021 is a long way from the next election (presidential or congress) and defense of the markets may not be so supportive at $6T or $10T per market smash. The FED may hesitate, and that will be window for stocks to break lower.

The 36 month simple moving a...

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Lee's Free Thinking

These Charts Show COVID 19 Is Spreading in the US and Will Kill the Economy

 

These Charts Show COVID 19 Is Spreading in the US and Will Kill the Economy

Courtesy of  

The COVID 19 pandemic is, predictably, worsening again in much of the US. Only the Northeast, and to a lesser extent some Midwestern states, have been consistently improving. And that trend could also reverse as those states fully reopen.

The problem in the US seems to be widespread public resistance to recommended practices of social distancing and mask wearing. In countries where these practices have been practi...



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Members' Corner

Coronavirus, 'Plandemic' and the seven traits of conspiratorial thinking

 

Coronavirus, 'Plandemic' and the seven traits of conspiratorial thinking

No matter the details of the plot, conspiracy theories follow common patterns of thought. Ranta Images/iStock/Getty Images Plus

Courtesy of John Cook, George Mason University; Sander van der Linden, University of Cambridge; Stephan Lewandowsky...



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Insider Scoop

Economic Data Scheduled For Friday

Courtesy of Benzinga

  • Data on nonfarm payrolls and unemployment rate for March will be released at 8:30 a.m. ET.
  • US Services Purchasing Managers' Index for March is scheduled for release at 9:45 a.m. ET.
  • The ISM's non-manufacturing index for March will be released at 10:00 a.m. ET.
  • The Baker Hughes North American rig count report for the latest week is scheduled for release at 1:00 p.m. ET.
...

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Promotions

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Phil will discuss positions, COVID-19, market volatility -- the selloff -- and more! 

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Mike will show off the TradeExchange's new platform which you can try for free.  

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Mapping The Market

How IPOs Are Priced

Via Jean Luc 

Funny but probably true:

...

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Philip R. Davis is a founder Phil's Stock World, a stock and options trading site that teaches the art of options trading to newcomers and devises advanced strategies for expert traders...

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Ilene is editor and affiliate program coordinator for PSW. Contact Ilene to learn about our affiliate and content sharing programs.