Posts Tagged ‘stem cells’

High doses of antioxidant supplements induce stem cell genetic abnormalities

This is interesting, and important if you’re taking lots of supplements thinking that the more antioxidants you take, the longer you’ll live. Research is providing plenty of evidence that it doesn’t work so simply, while supplements fail to act according to the logical prevailing theory. Here’s another piece. – Ilene  

High doses of antioxidant supplements induce stem cell genetic abnormalities

Spoonful of dietary supplements

Courtesy of David Granovsky, in SCIENCE & STEM CELLS 

High doses of antioxidant supplements induce stem cell genetic abnormalities

High doses of antioxidant nutritional supplements, such as vitamins C and E, can increase genetic abnormalities in cells, which may predispose supplement-takers to developing cancer, according to a new study from the Cedars-Sinai Heart Institute.

The study, led by Eduardo Marbán, M.D., Ph.D., director of the Cedars-Sinai Heart Institute, was published online today in the medical journal Stem Cells. The study also will appear in the journal’s July printed edition.

Marbán and his team accidentally discovered the danger of excessive antioxidant doses while seeking a way to reduce the genetic abnormalities that occurred naturally when the scientists sought to multiply human cardiac stem cells.

Marbán stressed that the study’s finding applies only to excessive  and not to foods that are rich in antioxidants, such as milk, oranges, blueberries and peanuts. In recent years, multiple studies have touted the benefits of foods rich in antioxidants.

“Taking one multivitamin daily is fine, but a lot of people take way too much because they think if a little is good, a lot must be better,” said Marbán, who is also the Mark Siegel Family Professor at Cedars-Sinai. “That is just not the case. If you are taking 10 or 100 times the amount in a daily multivitamin, you may be predisposing your cells to developing cancer, therefore doing yourself more harm than good.”

In laboratories, stem cells are often grown in a Petri dish culture than is composed of 20 percent oxygen, whereas cells growing inside human tissue are exposed to just 3 to 5 percent oxygen. But Marbán’s team of researchers became frustrated because the higher concentration of oxygen in lab-grown stem cells resulted in 9 percent of the cells being rejected because of genetic abnormalities.

“We sought to counter that oxidation problem by adding high doses of antioxidants directly to
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A Stem-Cell Discovery Could Help Diabetics

A Stem-Cell Discovery Could Help Diabetics

By Alice Park, courtesy of TIME

Human-induced pluripotent stem cells
Human-induced pluripotent stem cells appear
Shinya Yamanaka / AP

Researchers are inching ever closer to bringing the latest stem-cell technologies from bench to bedside — and are, in the process, learning more about some diseases that long have remained medical black boxes.

This week, scientists at the Harvard Stem Cell Institute (HSCI) reported the first success in generating new populations of insulin-producing cells using skin cells of Type 1 diabetes patients. The achievement involved the newer embryo-free technique for generating stem cells, and marked the first step toward building a treatment that could one day replace a patient’s faulty insulin-making cells with healthy, functioning ones.

The experiment, published in the Proceedings of the National Academy of Sciences, also provided the first good model — in a petri dish — of how Type 1 diabetes develops, giving scientists a peek at what goes wrong in patients affected by the disease. Such knowledge could lead to not only new stem-cell-based treatments, but also novel drug therapies that might improve the symptoms of the disease.

Douglas Melton, co-director of HSCI, and his team took skin cells from two Type 1 diabetes patients, exposed the cells to a cocktail of three genes that converted them back to an embryonic state — which are referred to as pluripotent stem cells — then instructed the newly reborn cells to grow into beta cells, the cells in the pancreas that secrete insulin. In Type 1 diabetes, these beta cells no longer work to break down the glucose that floods the body after each meal, leading to blood-sugar spikes that can damage the kidneys and heart.

To test whether their lab-made cells could function like normal beta cells, Melton’s group exposed them to glucose in a dish. When sugar levels were high, the cells produced more of a protein that beta cells release when they break down sugar; when glucose levels were low, the protein levels were low as well.

"These cells represent the newest model of diabetes for humans," says Melton. "We have a lot of good models of Type 1 diabetes in the mouse, but everything that we have learned from them has failed in the clinic. Now we have a chance at figuring out how humans get the disease."…
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Zero Hedge

Lois Lerner Of 2021: IRS Political Corruption Unchanged With Billionaires' Tax Returns

Courtesy of ZeroHedge View original post here.

Authored by Emily Miller via Emily Post News

When the private tax returns of billionaires were leaked to a left-wing group, liberals and conservatives reacted very differently. Liberals fell for the political trick and immediately said that the tax code was unfair and the rich should get a tax hike. Conservatives saw through the conspiracy and wanted answers on how the Deep State at the IRS could, once again, have so much unchecked power for political purpo...



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Phil's Favorites

The PhilStockWorld com LIVE Weekly Webinar 06-16-2021

 

For LIVE access on Wednesday afternoons, join us at PSW! 

The PhilStockWorld com LIVE Weekly Webinar 06-09-2021

 

Major Topics:
00:00:14 - Checking on the Market
00:01:42 - EIA Report
00:09:50 - Intermediate Goods / Final Demand PPI / Inflation
00:16:13 - GOOGL
00:17:05 - MSFT / AA / AAPL
00:20:09 - U.S. Wage Growth
00:26:42 - U.S Housing Market / Wage Gap
00:34:47 - Mortgage & Property Taxes
00:37:16 - LTP
00:39:25 - STP
00:40:01 - CMG / FX / TQQQ
00:40:17 - SQQQ / W 
00:45:40 - LTP
00:49...



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Biotech/COVID-19

A mix-and-match approach to COVID-19 vaccines could provide logistical and immunological benefits

 

A mix-and-match approach to COVID-19 vaccines could provide logistical and immunological benefits

One of this and one of that might be a good strategy to coronavirus vaccination. SOPA Images/LightRocket via Getty Images

Courtesy of Maureen Ferran, Rochester Institute of Technology

While it’s now pretty easy to get a COVID-19 shot in most places in the U.S., the vaccine rollout in other parts of the world has been slow or inconsistent due to ...



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Chart School

Gold Seasonals and T Theory Cycle Review

Courtesy of Read the Ticker

Gold tends to slump at the start of the US summer, and will Basel 3 make a difference this year?

Basel 3 has removed a large chuck of paper shorts off the LBMA, of course this is for the banks only, the hedge funds can continue to suppress gold with paper shorts. The true effect of Basel 3 may not be known for some month. 


A typical pattern in the metals is a smash down just before a major rally, consider this:


POINT 1: IRD recent post did say this

..."I’m wondering if the entire 'Kabuki Theatre' production is being staged to...



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Politics

The Ukraine Fallacies (with Victor Rud)

 

The Ukraine Fallacies (with Victor Rud)

Americans are confused about the history of Ukraine. That's just how Russia wants it.

Courtesy of Greg Olear, at PREVAIL

Greg is the author of Dirty Rubles: An Introduction to Trump/Russia 

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Promotions

Live Webinar with Phil on Option Strategies

 

June is TD Bank's Option Education Month, and today (Thursday, June 10) at 1 pm EST, Phil will speak with host Bryan Rogers about selling options and various option strategies that we use here at Phil's Stock World. Don't miss this event!

Click here to register for TD's live webinar with Phil.

 

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Digital Currencies

Crypto: Congress Dawdles as $1.7 Trillion Con-Game Goes Unregulated, Threatening Reputation of U.S. Markets

Courtesy of Pam Martens

If you want to get your hair cut outside of your home in the United States, the job has to be done by a licensed worker at a regulated business. The same thing applies to plumbers, electricians, home inspectors, real estate and insurance agents. They all require a license and are subject to regulatory scrutiny.

Likewise, commodities like corn, sugar, wheat, lumber and oil are all traded on regulated exchanges which are overseen by a federal regulator.

But, for reasons that have yet to be explained to the American people, when it comes to the $1.7 trillion cryptocurrency market – which is effectively a con-g...



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Kimble Charting Solutions

Crude Oil Cleared For Blast Off On This Dual Breakout?

Courtesy of Chris Kimble

Is Crude Oil about to blast off and hit much higher prices? It might be worth being aware of what could be taking place this month in this important commodity!

Crude Oil has created lower highs over the past 13-years, since peaking back in 2008, along line (1).

It created a “Double Top at (2), then it proceeded to decline more than 60% in four months.

The countertrend rally in Crude Oil has it attempting to break above its 13-year falling resistance as well as its double top at (3).

A successful breakout at (3) would suggest Crude Oil is about to mo...



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ValueWalk

Managing Investments As A Charity Or Nonprofit

By Anna Peel. Originally published at ValueWalk.

Maintaining financial viability is a constant challenge for charities and nonprofit organizations.

Q4 2020 hedge fund letters, conferences and more

The past year has underscored that challenge. The pandemic has not just affected investment returns – it’s also had serious implications for charitable activities and the ability to fundraise. For some organizations, it’s even raised doubts about whether they can continue to operate.

Finding ways to generate long-term, sustainable returns for ...



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Mapping The Market

Suez Canal: Critical Waterway Comes to a Halt

 

Suez Canal: Critical Waterway Comes to a Halt

Courtesy of Marcus Lu, Visual Capitalist

The Suez Canal: A Critical Waterway Comes to a Halt

On March 23, 2021, a massive ship named Ever Given became lodged in the Suez Canal, completely blocking traffic in both directions. According to the Suez Canal Authority, the 1,312 foot long (400 m) container ship ran aground during a sandstorm that caused low visibility, impacting the ship’s navigation. The vessel is owned by Taiwanese shipping firm, Evergreen Marine.

With over 2...



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The Technical Traders

Adaptive Fibonacci Price Modeling System Suggests Market Peak May Be Near

Courtesy of Technical Traders

Our Adaptive Fibonacci Price Modeling system is suggesting a moderate price peak may be already setting up in the NASDAQ while the Dow Jones, S&P500, and Transportation Index continue to rally beyond the projected Fibonacci Price Expansion Levels.  This indicates that capital may be shifting away from the already lofty Technology sector and into Basic Materials, Financials, Energy, Consumer Staples, Utilities, as well as other sectors.

This type of a structural market shift indicates a move away from speculation and towards Blue Chip returns. It suggests traders and investors are expecting the US consumer to come back strong (or at least hold up the market at...



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Lee's Free Thinking

Texas, Florida, Arizona, Georgia - The Branch COVIDIANS Are Still Burning Down the House

 

Texas, Florida, Arizona, Georgia – The Branch COVIDIANS Are Still Burning Down the House

Courtesy of Lee Adler, WallStreetExaminer 

The numbers of new cases in some of the hardest hit COVID19 states have started to plateau, or even decline, over the past few days. A few pundits have noted it and concluded that it was a hopeful sign. 

Is it real or is something else going on? Like a restriction in the numbers of tests, or simply the inability to test enough, or are some people simply giving up on getting tested? Because as we all know from our dear leader, the less testing, the less...



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Insider Scoop

Economic Data Scheduled For Friday

Courtesy of Benzinga

  • Data on nonfarm payrolls and unemployment rate for March will be released at 8:30 a.m. ET.
  • US Services Purchasing Managers' Index for March is scheduled for release at 9:45 a.m. ET.
  • The ISM's non-manufacturing index for March will be released at 10:00 a.m. ET.
  • The Baker Hughes North American rig count report for the latest week is scheduled for release at 1:00 p.m. ET.
...

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