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Why Mitochondria Matter

Patrick starts by reviewing what a "broken record" is. (Sadly, I know and you probably do too.) He notes that biotechnology has undergone more enormous changes than the music delivery industry, and that most people do not have a proper appreciation of how big this "biotech transformation" is. Then, he reviews what mitochondria are, how they work and why they are so important to us.

Within all the cells of our bodies, microchondria produce energy - the energy supply needed to run the cells' activities. Without the ability to take nutrients and convert them to energy, via these little cellular machines, we are dead. And that, in brief, is why mitochondria are important. 

Illustration of a Mitochondrion by Kelvinsong, modified by Sowlos, posted on Wikipedia.

?

TransTech Digest: Why Mitochondria Matter

By Patrick Cox

I may sound like a broken record saying this again, but it’s critical that we realize that scientific understanding of the biological world is increasing at an exponential rate. For younger readers, I should explain that the term “broken record” is a reference to a common failure of the old pressed-vinyl audio recording technology. Occasionally, the spiraled groove on a record imprinted with physical representations of sound would be scratched or otherwise damaged. As a result, the needle that transferred analog information to the amplifier would be knocked outward from the groove to play the same section of the recording over and over again.

For those of you who already knew this, it’s useful to realize that the technology of audio recording that was once universal is not just obsolete, most younger people don’t even know what a skipping record is today. The reason that this is such a useful realization is that biotechnology has undergone even bigger changes than the transformation of recorded music from bumps in vinyl grooves to streamed electrons. Most people, however, have no real appreciation of how big the ongoing biotech transformation really is.

New tools let us see deep into the atomically precise world of molecular biology. Just as important is a growing base of biological knowledge that is available to anybody. Though Google Scholar is only 10 years old, I find it hard to imagine a…
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Tim Cook: “I’m Proud to be Gay”

 

Tim Cook discusses being gay on BusinessWeek. Recent bullying statistics show that gay teens are from 2 to 3 times more likely to commit suicide than others, and almost 30% of completed suicides are related to problems dealing with sexual identity. Perhaps Tim Cook's story will help people accept their differences, whatever they are, and move on to achieve their goals. 

Excerpt:

Being gay has given me a deeper understanding of what it means to be in the minority and provided a window into the challenges that people in other minority groups deal with every day. It’s made me more empathetic, which has led to a richer life. It’s been tough and uncomfortable at times, but it has given me the confidence to be myself, to follow my own path, and to rise above adversity and bigotry. It’s also given me the skin of a rhinoceros, which comes in handy when you’re the CEO of Apple.

The world has changed so much since I was a kid. America is moving toward marriage equality, and the public figures who have bravely come out have helped change perceptions and made our culture more tolerant. Still, there are laws on the books in a majority of states that allow employers to fire people based solely on their sexual orientation. There are many places where landlords can evict tenants for being gay, or where we can be barred from visiting sick partners and sharing in their legacies. Countless people, particularly kids, face fear and abuse every day because of their sexual orientation.

I don’t consider myself an activist, but I realize how much I’ve benefited from the sacrifice of others. So if hearing that the CEO of Apple is gay can help someone struggling to come to terms with who he or she is, or bring comfort to anyone who feels alone, or inspire people to insist on their equality, then it’s worth the trade-off with my own privacy.

Full article: Tim Cook: "I'm Proud to be Gay" – Businessweek.

Zero Hedge commented on Cook's admission here and shared…
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Comment by phil

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  1. phil

    SPY  5  MINUTEGood morning!  

    Interesting action as the Dollar is still ripping higher, now 86.50 but the Futures are up about 0.3% anyway. 

    Not so much commodities, they are getting whacked with oil back to $81.50 (from $82.88 high), gold $1,203, silver $16.77, copper $3.075, nat gas $3.79 and gasoline $2.17.

    Considering the BIG picture, what's going on at the moment is the strong Dollar is goosing the global markets, with the Nikkei at 15,775 (up 100) and Shanghai up 0.76%, India up 0.77% but Hang Seng down 0.5% as they can't get rid of those protesters (and housing prices are falling).  They Yen is testing 110 (109.25), so of course the Nikkei is happy (lowers their export prices).  

     

    Europe is totally thrilled that we're done easing as it makes their easing so much more effective.  The Euro dove to $1.256, down from $1.40 in May, so down 10% in 6 months to "stimulate" their economy. Think about that, their currency is down 10% yet they are still in deflation – that means people aren't buying ANYTHING.  

    /ES just got rejected at 1,180 and that's still a bearish signal and we can short them below the line or be more aggressive shorting /TF at 1,145 — buy you know how scary that can be.  If /ES goes over 1,180 – GET OUT OF THE SHORT POSITION!  If /TF goes over 1,145 – GET OUT OF THE SHORT POSITION.

    RUT WEEKLY

    SPX WEEKLY

     Simple plan, right?  For reference, we missed /YM 16,995 because under 17,000 is also a great short line (now 16,965) and /NQ is 4,082 and below 4,080 confirms a shorting premise and, of course, watch the Dollar, which is likely to be rejected at 86.50 and a lower Dollar makes shorting more dangerous so quick profit-taking is also a must.  

    Fed Closes Chapter on Easy MoneyBenefit of


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Outside the Box: The Colder War

Outside the Box: The Colder War

By John Mauldin

The story of energy is the story of human expansion. From the days when we roamed the African savanna, we tamed first fire and then other forms of energy, using them as tools to control our environment and improve our lives. The control of energy has always been at the heart of the human story.

This week our Outside the Box essay is from my friend Marin Katusa, who has written a fascinating book about a part of that story, a subplot of intrigue and conspiracy. Under Putin, Russia has aspired to dominate the energy markets. Called The Colder War, Marin’s book is a well-written tale of the rise of Putin and his desire to change the way the world’s energy markets are controlled.

I sat down a few months ago with an advance copy, not sure what to expect. Marin is personally very colorful and entertaining, but would that charisma translate to words on a page? I started on a Sunday afternoon and finished before I laid my head on the pillow that night. The Colder War was an entertaining and gripping story of the rise of Putin and the shifting sands of the world of oil. It was also an insightful overview of the last century. I highly recommend it.

At the end of the day, I disagree with Marin as to Putin’s ability to achieve his vision. While Putin wants to displace the petro-dollar as the global medium of energy exchange, he will fail. But maybe that’s the hometown boy in me thinking my team will win.

But that is the last 10% of the book. The first 90% is an easy must-read. Warning: it is not written from a US perspective. Marin’s view of the events of the last century sound more like those I hear when I travel outside the US.

I took the liberty of checking his story with a good friend of mine, Jerry Fullenwider, a very successful Texas oil entrepreneur, who lived in Russia during Putin’s rise. He confirmed Marin’s tales and more. He has his history right. And what a history it is. Today’s OTB is the introduction to the book, and if…
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Orbital Sciences Shares Crash After Its Unmanned Rocket Explodes

Orbital Sciences Shares Crash After Its Unmanned Rocket Explodes

By  at Business Insider

Antares 1

YouTube/Brad Panovich

Orbital Sciences' Antares rocket exploded shortly after takeoff Tuesday night.

And now the company's shares are crashing as well.

In premarket trade on Wednesday, Orbital Sciences shares were down more than 15% after the company's unmanned Antares rocket exploded shortly after taking off for the International Space Station with about 5,000 pounds of supplies.

In a statement, Orbital Sciences said that shortly after takeoff the rocket experienced a "catastrophic failure."

No was hurt in the incident. 

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Which Way Wednesday – Ridiculously Overbought Edition

NYMO  DAILYCheck out this chart:  

That's the NYSE McClellen Oscillator, which hasn't been this high (overbought) since July of 2011, when the S&P plunged from 1,345 to 1,123 (16.5%) in 4 terrifying weeks.  Yesteday's rally was a very low-volume affair 101.3M on SPY (about 60% of normal) and we were goosed by Peter Schiff on CNBC at 1:10 pm, claiming QE4 was right around the corner:

Ahead of tomorrow's decision by the FOMC, Peter Schiff ventured on to CNBC to discuss the economy, the fed, and gold… among other things. Schiff rightly fears that while the Fed may well stop QE3 tomorrow, QE4 will not be too long behind it as he notes, rather eloquently, that "an economy that lives by QE, will die by QE" as the Fed's total lack of willingness to allow stocks to fall (see Bullard 2 weeks ago) or a 'cleansing' recession leaves the nation's economy in far worse shape than it was before the Fed's intervention. Schiff calmly replies to the anchor's questions (as she proclaims "I am not on the side of the Fed but…"), gently explains his view on gold when challenged about his 'wrongness', but when a guest starts hounding him for being dangerous to CNBC viewers wealth… Schiff (rightly) loses it – must watch!

SPY  5  MINUTEAs noted by Dave Fry:

It seems bulls are confident the Fed will end QE on schedule and at the same time give bulls dovish comments about conditions (“don’t mess with us”!) going forward. Many pundits are discussing interest rates remaining unchanged for several years and longer.

That means companies like IBM can continue (another $5 billion share buyback announced today) their financial engineering to lessen float making it easy to report better earnings at the price of future innovation and company growth. But bulls don’t care about future growth, only what takes place now. Besides, this is the


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ROSENBERG: Bear Markets Don’t Just Happen – They’re Caused By These Two Conditions

ROSENBERG: Bear Markets Don't Just Happen — They're Caused By These Two Conditions

Courtesy of 

Gluskin Sheff's David Rosenberg isn't rattled by the recent volatility in the financial markets.

"For stocks, it always comes down to the Fed and the economy," Rosenberg said to Business Insider.

"The reality is that bear markets do not just pop out of the air," he wrote. "They are caused by tight money, recessions, or both. These conditions do not apply, nor will they until 2016 at the earliest."

We recently asked Rosenberg for what he considered to be the Most Important Chart In The World. He sent us this annotated chart of the year-over-year percent change in the S&P 500. As you can see, the big plunges indeed came during recessions and monetary tightening cycles.

Based on the trends in the Conference Board's Leading Economic Index, a recession is "at least two years away," Rosenberg said. "That is one peg — the expansion being sustained. The other is the Fed policy, and any actual rate hikes now seem to be more of a 2015 than a 2016 story."

The Federal Reserve concludes its two-day Federal Open Market Committee meeting on Wednesday, at which point we may get some clues regarding the timing of the Fed's first rate hike. For now, all we know is it's a considerable ways off.

cotd stocks recession fed

Gluskin Sheff

SEE ALSO:  WALL STREET'S BRIGHTEST MINDS REVEAL THE MOST IMPORTANT CHARTS IN THE WORLD

 





Chris Hedges: The Myth of a Free Press

Chris Hedges: The Myth of a Free Press

Courtesy of Jesse's Cafe Americain

The bias in the US media towards corporate and special interests is apparent in some sources more easily and readily than in others, especially if one has access and bothers to look at a broad base of international news sources.  

The great change was institutionalized with the overturn of the Fairness Doctrine under Reagan in 1985 and the revoking of media ownership restrictions from 1934 and 1975 under the Clinton administration's Telecommunications Act of 1996.

What has changed perhaps is the extreme marginalization of independent sources.  For the most part media outlets declare themselves for one group or another.  The bias of the financial media in policy issues has become so obvious and servile to its corporate interests that it is almost embarrassing.  What is even more surprising is the reach of this sort of continuous advocacy journalism into 'mainstream' channels such as Fox and MSNBC that actively re-interpret reality to suit a class of viewers.  

This balkanization of the issues attracts large classes of listeners into group think, and precludes any meaningful debate of the issues, even to the very framing of the questions and the issues, and ultimately their very perception of reality.

This is a brief excerpt.  Read the entire article for free here.

"The mass media blindly support the ideology of corporate capitalism. They laud and promote the myth of American democracy—even as we are stripped of civil liberties and money replaces the vote. They pay deference to the leaders on Wall Street and in Washington, no matter how perfidious their crimes. They slavishly venerate the military and law enforcement in the name of patriotism. 

They select the specialists and experts, almost always drawn from the centers of power, to interpret reality and explain policy. They usually rely on press releases, written by corporations, for their news. And they fill most of their news holes with celebrity gossip, lifestyle stories, sports and trivia. The role of the mass media is to entertain or to parrot official propaganda to the masses. 

The corporations, which own the press, hire journalists willing to be courtiers to the elites, and they promote them as celebrities. These journalistic courtiers, who can earn


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The Gift that Keeps on Giving

The Gift that Keeps on Giving

Courtesy of Wade of Investing Caffeine

Christmas Present Wrapped in Gold and Silver

There have been numerous factors contributing to this bull market, even in the face of a slew of daunting and exhausting headlines. Contributing to the advance has been a steady stream of rising earnings; a flood of price buoying stock buybacks; and the all-important gift of growing dividends that keep on giving. Bonds have benefited to a lesser extent than stocks over the last five years in part because bonds lack the gift of rising dividend payouts. Life would be grander for bondholders, if the issuers had the heart to share generous news like this:

“Good day Mr. & Mrs. Jones. As your bond issuer, we value our mutually beneficial relationship so much that we would like to reward you as a bond investor. In addition to the 2.5% we are paying you now, we have decided to increase your annual payments by 6% per year for the next 20 years. In other words, we will increase your $2,500 in annual interest payments to over $8,000 per year. But wait…there’s more! You are such great people, we are going to increase the value of your initial $100,000 investment to $450,000.”

Does this sound too good to be true? Well, it’s not…sort of. However, the scenario is absolutely true, if you invested $100,000 in S&P 500 stocks during 1993 and held that investment until today. Unfortunately, the gift giving conversation above would be unattainable and the furthest from the truth, if you invested $100,000 into bonds. Today, if you decided to invest $100,000 in 20-year government bonds paying 2.5%, your $2,500 in annual payments will never increase over the next two decades. What’s more, by 2034 your initial principal of $100,000 won’t increase by a penny, while inflation slowly but surely crushes your investment’s purchasing power.

To illustrate the magical power of dividend compounding at a 6% CAGR, here is a chart of the S&P 500 dividend stream over the 21-year period of 1993 – 2014:

SP500 Dividends 1993-2014

The trend of increasing dividends doesn’t appear to be slowing either. Here is a table showing the number of S&P 500 companies increasing their dividend payouts:

COUNT OF DIVIDEND ACTIONS YEAR-TO-DATE INCREASING THEIR


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Help One Of Our Own PSW Members

"Hello PSW Members –

This is a non-trading topic, but I wanted to post it during trading hours so as many eyes can see it as possible.  Feel free to contact me directly at jennifersurovy@yahoo.com with any questions.

Last fall there was some discussion on the PSW board regarding setting up a YouCaring donation page for a PSW member, Shadowfax. Since then, we have been looking into ways to help get him additional medical services and to pay down his medical debts.  After following those leads, we are ready to move ahead with the YouCaring site. (Link is posted below.)  Any help you can give will be greatly appreciated; not only to help aid in his medical bill debt, but to also show what a great community this group is.

http://www.youcaring.com/medical-fundraiser/help-get-shadowfax-out-from-the-darkness-of-medical-bills-/126743

Thank you for you time!

 
 

Phil's Favorites

Chris Martenson and Mish Audio on Bank of Japan's Surprise Move on Friday

Courtesy of Mish.

Every other Wednesday or so, Chris Martenson and I get together for a podcast. Sometimes one of us or the other is out of town, and sometimes Chris has other guest speakers.

Because of scheduling difficulties, Chris and I got together today instead of Wednesday. I asked Chris to make today's podcast generally available.

For our take of Friday's BoJ surprise move, please play the audio on Chris' Peak Prosperity site: Off the Cuff: Japanese Central Bank Throws Granny Under the Bus.

The audio is about 25 minutes long. The podcasts are not scripted. Chris and I just talk "off the cuff" on events of the day or the week.

Mike "Mish" Shedlock
http://globaleconomicanalysis.blogspot.com

...

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Zero Hedge

The Story Changes: Ebola Is Now "Aerostable" And Can Remain On Surfaces For 50 Days

Courtesy of ZeroHedge. View original post here.

Submitted by Tyler Durden.

Submitted by Michael Snyder of The End of the American Dream blog,

When it comes to Ebola, the story that the government is telling us just keeps on changing.  At first, government officials were claiming that it was very difficult to spread the Ebola virus.  Some of them were even comparing it to HIV.  We were given the impression that we had to have “direc...



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Chart School

Moving Averages: Month-End Update

Courtesy of Doug Short.

Valid until the market close on November 28, 2014

The S&P 500 closed September with a monthly gain of 2.32%. All three S&P 500 MAs and three of the five the Ivy Portfolio ETF MAs are signaling "Invested".

The Ivy Portfolio

The table below shows the current 10-month simple moving average (SMA) signal for each of the five ETFs featured in The Ivy Portfolio. I've also included a table of 12-month SMAs for the same ETFs for this popular alternative strategy.

For a facinating analysis of the Ivy Portfolio strategy, see this article by Adam Butler, Mike Philbrick and Rodrigo Gordillo:

  • ...


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Market Shadows

When one door closes...

Predictions that the US equity market would collapse at the end of QE have so far been wrong (and in a very painful way if you shorted the market based on the Fed's actions alone). The end-of-the-world-QE bears failed to factor in another surprise move by the Bank of Japan. The BOJ announced its own QE program today -- it is donating $124Bn ($80 trillion yen) to the market-propping cause. It plans to triple the amount of Japanese ETFs and REITs it buys on the open market.

As  at Business Insider wrote on Oct. 26, If You Missed The Rally, Then You Just Made The Most Classic Mistake In Investing. Since then, the market continues higher...

...

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All About Trends

Mid-Day Update

Reminder: David is available to chat with Members, comments are found below each post.

Click here for the full report.




To learn more, sign up for David's free newsletter and receive the free report from All About Trends - "How To Outperform 90% Of Wall Street With Just $500 A Week." Tell David PSW sent you. - Ilene...

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Sabrient

Sector Detector: Bullish conviction returns, but market likely to consolidate its V-bottom

Courtesy of Sabrient Systems and Gradient Analytics

Bulls showed renewed backbone last week and drew a line in the sand for the bears, buying with gusto into weakness as I suggested they would. After all, this was the buying opportunity they had been waiting for. As if on cue, the start of the World Series launched the rapid market reversal and recovery. However, there is little chance that the rally will go straight up. Volatility is back, and I would look for prices to consolidate at this level before making an attempt to go higher. I still question whether the S&P 500 will ultimately achieve a new high before year end.

In this weekly update, I give my view of the current market environment, offer a technical analysis of the S&P 500 chart, review our weekly fundamentals-based SectorCast rankings of the ten U.S. business sectors, and then o...



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OpTrader

Swing trading portfolio - week of October 27th, 2014

Reminder: OpTrader is available to chat with Members, comments are found below each post.

 

This post is for all our live virtual trade ideas and daily comments. Please click on "comments" below to follow our live discussion. All of our current  trades are listed in the spreadsheet below, with entry price (1/2 in and All in), and exit prices (1/3 out, 2/3 out, and All out).

We also indicate our stop, which is most of the time the "5 day moving average". All trades, unless indicated, are front-month ATM options. 

Please feel free to participate in the discussion and ask any questions you might have about this virtual portfolio, by clicking on the "comments" link right below.

To learn more about the swing trading virtual portfolio (strategy, performance, FAQ, etc.), please click here ...



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Stock World Weekly

Stock World Weekly

Newsletter writers are available to chat with Members regarding topics presented in SWW, comments are found below each post.

Here's the latest Stock World Weekly. Enjoy!

(As usual, use your PSW user name and password to sign in. You may also take a free trial.) 

 

#455292918 / gettyimages.com

 

...

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Option Review

LUV Options Active Ahead Of Earnings

There is lots of action in Southwest Airlines Co. November expiry call options today ahead of the air carrier’s third-quarter earnings report prior to the opening bell on Thursday. Among the large block trades initiated throughout the trading session, there appears to be at least one options market participant establishing a call spread in far out of the money options. It looks like the trader purchased a 4,000-lot Nov 37/39 call spread at a net premium of $0.40 apiece. The trade makes money if shares in Southwest rally 9.0% over the current price of $34.32 to exceed the effective breakeven point at $37.40, with maximum potential profits of $1.60 per contract available in the event that shares jump more than 13% to $39.00 by expiration. In September, the stock tou...



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Digital Currencies

Goodbye War On Drugs, Hello Libertarian Utopia. Dominic Frisby's Bitcoin: The Future of Money?

Courtesy of John Rubino.

Now that bitcoin has subsided from speculative bubble to functioning currency (see the price chart below), it’s safe for non-speculators to explore the whole “cryptocurrency” thing. So…is bitcoin or one of its growing list of competitors a useful addition to the average person’s array of bank accounts and credit cards — or is it a replacement for most of those things? And how does one make this transition?

With his usual excellent timing, London-based financial writer/actor/stand-up comic Dominic Frisby has just released Bitcoin: The Future of Money? in which he explains all this in terms most readers will have no tr...



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Pharmboy

Biotechs & Bubbles

Reminder: Pharmboy is available to chat with Members, comments are found below each post.

Well PSW Subscribers....I am still here, barely.  From my last post a few months ago to now, nothing has changed much, but there are a few bargins out there that as investors, should be put on the watch list (again) and if so desired....buy a small amount.

First, the media is on a tear against biotechs/pharma, ripping companies for their drug prices.  Gilead's HepC drug, Sovaldi, is priced at $84K for the 12-week treatment.  Pundits were screaming bloody murder that it was a total rip off, but when one investigates the other drugs out there, and the consequences of not taking Sovaldi vs. another drug combinations, then things become clearer.  For instance, Olysio (JNJ) is about $66,000 for a 12-week treatment, but is approved for fewer types of patients AND...



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About Phil:

Philip R. Davis is a founder Phil's Stock World, a stock and options trading site that teaches the art of options trading to newcomers and devises advanced strategies for expert traders...

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About Ilene:

Ilene is editor and affiliate program coordinator for PSW. She manages the site market shadows, archives, more. Contact Ilene to learn about our affiliate and content sharing programs.

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