Consider this: of the trillions upon trillions of cells in the human body, only about 1 in 10 is actually human. The rest belong to microbes, which colonize every inch of you, from the inside of your mouth to the skin between your toes. It’s no wonder, then, that research is increasingly finding that the diversity of these microbes has important effects on health.
The vast majority of microbes — perhaps up to 100 trillion of them — live in our guts. So-called gut bugs help digest our food, assist our immune systems, maintain the health of the intestines, produce vitamins, aid metabolism and extract calories from food (which is why much research has associated gut bugs with obesity).
To better understand the way gut bugs work, a new study has aimed to categorize the lot of them. The study, led by Peer Bork of the European Molecular Biology Laboratory in Heidelberg, Germany, found that the bacteria in our guts falls into one of three distinct ecosystems, or "enterotypes."
"The three gut types can explain why the uptake of medicines and nutrients varies from person to person," Jeroen Raes, a bioinformatician at Vrije University in Brussels and coauthor of the new study, said in a statement. Which means that knowing a person’s enterotype could someday help doctors tailor drug treatments or diets to suit them better.
Or, [Bork] speculated, doctors might be able to use enterotypes to find alternatives to antibiotics, which are becoming increasingly ineffective. Instead of trying to wipe out disease-causing bacteria that have disrupted the ecological balance of the gut, they could try to provide reinforcements for the good bacteria. "You’d try to restore the type you had before," he said.
For the new study, the research team evaluated stool samples from 22 European individuals, extracted the DNA and determined its composition by using DNA analysis and computers. They also compared the results to other published findings from Japanese and American subjects.
Scientists found that each of the three enterotypes was composed of a unique balance of microbe species. The team named each type after its dominant bacteria: Bacteroides, an enterotype that’s known to break down carbohydrates and is better at making vitamins B2, B5, C and H; Prevotella, which degrades mucus and produces more B1 and folic acid; and Ruminococcus, which…
Interesting study – the researchers controlled for exercise, weight, blood pressure, smoking and other factors correlated to vascular events, including strokes. So what might be the problem with diet soda? Perhaps the artificial sweetner itself (Aspartame/Nutrasweet?). Drinking sugary soda was not significantly correlated with an increased risk for vascular events. - Ilene
LOS ANGELES (AP) — It’s not definitive proof of harm, but new research raises concern about diet soda. It suggests that people who drink it every day have higher risks for stroke and heart attack than those who drink no soda of any kind at all.
The findings come from a federally funded study of about 2,500 adults in the New York City area.
Doctors have no explanation for why diet soda might be risky. It could be that people who drink lots of it also fail to exercise, weigh more or have other risk factors like high blood pressure and smoking. However, the researchers took these factors into account and found the trend remained.
According to "Diet Soda May Heighten Risk for Vascular Events," the risk for "stroke, myocardial infarction, and vascular death," were elevated in the group that drank diet sodas every day. "People who had diet soda every day experienced a 61% higher risk of vascular events than those who reported drinking no soda," lead investigator Hannah Gardener, ScD, an epidemiologist from the University of Miami Miller School of Medicine in Florida, told reporters attending a news conference here at the International Stroke Conference.
Specifically, the University of Miami study (which followed more than 2,500 men and women aged 40 and older for an average of about nine years) found that people who drank diet soda daily were 61 percent more likely to experience a cardiovascular event than people who drank no diet soda.
That increase in risk held up after controlling for such factors as age, sex, smoking, physical activity and calories consumed each day. Even after the researchers controlled for metabolic syndrome and a history of heart disease, the people who drank diet soda daily had a 48 percent increased risk of having a stroke or heart attack compared to their non-diet soda drinking
One of the most contentious issues in the vast literature about alcohol consumption has been the consistent finding that those who don’t drink actually tend to die sooner than those who do. The standard Alcoholics Anonymous explanation for this finding is that many of those who show up as abstainers in such research are actually former hard-core drunks who had already incurred health problems associated with drinking.
But a new paper in the journal Alcoholism: Clinical and Experimental Research suggests that — for reasons that aren’t entirely clear — abstaining from alcohol does actually tend to increase one’s risk of dying even when you exclude former drinkers. The most shocking part? Abstainers’ mortality rates are higher than those of heavy drinkers.
Moderate drinking, which is defined as one to three drinks per day, is associated with the lowest mortality rates in alcohol studies. Moderate alcohol use (especially when the beverage of choice is red wine) is thought to improve heart health, circulation and sociability, which can be important because people who are isolated don’t have as many family members and friends who can notice and help treat health problems.
But why would abstaining from alcohol lead to a shorter life? It’s true that those who abstain from alcohol tend to be from lower socioeconomic classes, since drinking can be expensive. And people of lower socioeconomic status have more life stressors — job and child-care worries that might not only keep them from the bottle but also cause stress-related illnesses over long periods. (They also don’t get the stress-reducing benefits of a drink or two after work.)
But even after controlling for nearly all imaginable variables — socioeconomic status, level of physical activity, number of close friends, quality of social support and so on — the researchers (a six-member team led by psychologist Charles Holahan of the University of Texas at Austin) found that over a 20-year period, mortality rates were highest for those who had never been drinkers, second-highest for heavy drinkers and lowest for moderate drinkers.
The sample of those who were studied included individuals between ages 55 and 65 who had had any kind of outpatient care in the previous three years. The 1,824 participants were followed for 20 years. One drawback of the sample: a disproportionate number, 63%, were men. Just over…
Time waits for no man, the old truism goes, but in recent years scientists have shown that it does seem to move more slowly for some. Molecular biologists have observed that people’s cells often age at different rates, leading them to make a distinction between "chronological" and "biological age."
But the reason for the difference remains only vaguely understood. Environmental factors such as smoking, stress and regular exercise all seem to influence the rate at which our cells age. Now, for the first time, researchers have found a genetic link to cellular aging — a finding that suggests new treatments for a variety of age-related diseases and cancers.
The field of "biological aging" has in recent years focused on the long molecules of DNA contained in human cells called chromosomes. All chromosomes have protective caps at either end called telomeres. Each time a cell replicates itself (as it does before it dies), the telomeres shorten, like plastic tips fraying on the end of shoelace. Shortened telomeres have been linked to a host of age-related illnesses such as heart disease and certain cancers. (Scientists have yet to study whether telomeres influence a person’s appearance). Last year’s Nobel prize in medicine was awarded to three American scientists for their work in the field, and many scientists now believe telomeres are the closest we may come to identifying a biological clock — and our best bet for one day learning how to stop or turn back that clock.
To better understand the aging discrepancy, a team of researchers in Britain and The Netherlands scanned more than 500,000 genetic variations across the human genome. Using a population of nearly 12,000, they then attempted to pinpoint a genetic link to telomere length. (See how to prevent illness at any age.)
In a significant breakthrough, the team successfully identified that a particular gene sequence was associated with differences in telomere length between individuals. What’s more, the sequence was clustered near a gene called TERC, which is already known to play a role in the production of an enzyme called telomerase. Telomerase repairs telomeres when they shorten. "That was very exciting for us," says Professor Nilesh Samani, a cardiologist at the University of Leicester who co-led the research, published last week in Nature Genetics. "It gave us great…
Cosmopolitan dug through their archives to find a June 1982 issue featuring a very naked chap by the name of Scott Brown playing centerfold model. Flattering, in a certain light, but possibly problematic for Brown, who is running for Ted Kennedy’s United States Senate seat in Massachusetts. “Vote for Brown. He Has One Hell of a Stimulus Package,” the lady mag suggests as a slogan.
BOSTON (AP) – The race to succeed the late Sen. Edward M. Kennedy has turned into a proxy battle over the fate of President Barack Obama’s health care overhaul.
A once-pedestrian contest between Democrat Martha Coakley and Republican Scott Brown has coarsened with a week to go, as the two have cast themselves as custodians of the pivotal Senate vote to determine the bill’s fate.
"As the 41st senator, I can stop it," Brown said last week during a debate, highlighting his potential to be the breakthrough Senate vote that upholds a GOP filibuster.
How could a Republican win in a state that Obama carried by more than 20 points. It’s simple. Republicans are motivated by the chance to pull a gigantic upset and torpedo healthcare reform. Democrats aren’t so motivated, so the conventional wisdom is that the makeup of the electorate will be way different than it was last election day.
The remote, snow-swept expanses of northern Sweden are an unlikely place to begin a story about cutting-edge genetic science. The kingdom’s northernmost county, Norrbotten, is nearly free of human life; an average of just six people live in each square mile. And yet this tiny population can reveal a lot about how genes work in our everyday lives.
Norrbotten is so isolated that in the 19th century, if the harvest was bad, people starved. The starving years were all the crueler for their unpredictability. For instance, 1800, 1812, 1821, 1836 and 1856 were years of total crop failure and extreme suffering. But in 1801, 1822, 1828, 1844 and 1863, the land spilled forth such abundance that the same people who had gone hungry in previous winters were able to gorge themselves for months.
In the 1980s, Dr. Lars Olov Bygren, a preventive-health specialist who is now at the prestigious Karolinska Institute in Stockholm, began to wonder what long-term effects the feast and famine years might have had on children growing up in Norrbotten in the 19th century — and not just on them but on their kids and grandkids as well. So he drew a random sample of 99 individuals born in the Overkalix parish of Norrbotten in 1905 and used historical records to trace their parents and grandparents back to birth. By analyzing meticulous agricultural records, Bygren and two colleagues determined how much food had been available to the parents and grandparents when they were young.
Around the time he started collecting the data, Bygren had become fascinated with research showing that conditions in the womb could affect your health not only when you were a fetus but well into adulthood. In 1986, for example, the Lancet published the first of two groundbreaking papers showing that if a pregnant woman ate poorly, her child would be at significantly higher than average risk for cardiovascular disease as an adult. Bygren wondered whether that effect could start even before pregnancy: Could parents’ experiences early in their lives somehow change the traits they passed to their offspring?
It was a heretical idea. After all, we have had a long-standing deal with biology:…
John asks: "Why is the government trying to spread its public health message through children rather than parents?" Perhaps because a significant proportion of the nation’s parents distrust it and the pharmaceutical companies, so going straight to the kids may be a viable option. – Ilene
Remember when tobacco companies were accused of targeting children with advertisements and promotional items featuring cartoons?
Everyone thought it was terrible because children could be convinced smoking was cool by cartoons.
(Or something. This never made a whole lot of sense since we’ve never really had a child smoking problem in the United States. Sure sometimes kids will take a puff or two as an experiment but real smoking didn’t stop until much later and there was never any evidence that teenagers were convinced to start smoking because of cartoons.)
The thing that really creeped most people out was that the use of cartoons seemed aimed at undermining parental authority and influence, getting between kids and their mom and dad. Oh, and the fact that most people are convinced that smoking is deadly.
So what should we make of this advertisement promoting flu shots? Believe it or not, flu shots are pretty controversial. There are a lot of people who believe that serious health issues are associated with the shots, although the evidence for this seems scant. Many more people just don’t think the risk of childhood flu is really worth the quite common side effects, limited risks and cost of getting the shot.
And a few of us have figured out that you can pretty effectively be a free rider when it comes to vaccinations. When my brother enrolled his daughter in pre-school, he was told that chicken pox shots were mandatory. As a Roman Catholic, he objected to the vaccine on pro-life grounds (lung tissue from aborted fetuses are used to generate the vaccine) and pointed out that if everyone else at school was vaccinated, there’s no way his daughter would catch or spread the chicken pox. She was effectively but indirectly vaccinated.
In any case, the risks and benefits of getting a flu shot seem to be something that should be left up to parents rather than decided by bureaucrats. Certainly, the image of the
Back in August 2010, Zero Hedge was ostracized for daring to first point out the massive distortion to the US unemployment rate as a result of the collapse in the labor force participation rate, and the far less realistic modeling of the US labor force. We said that while the US unemployment rate was shown to be steadily declining, the real unemployment rate when one factors in a realistic participation rate is well above 10%. It still is.
Since then not only tenured Wall Street weathermen but Janet Yellen herself has admitted the unemployment rate is no longer a meaningfu...
In the strive for zero labor factories we are nearly there. Is 90% good enough?
China Daily reports Manufacturing Hub Starts Work on First Zero-Labor Factory. A manufacturing hub in South China's Guangdong province has begun constructing the city's first zero-labor factory, a signal that the local authorities are bringing into effect its "robot assembling line" strategy.
Dongguan-based private company Everwin Precision Technology Ltd is pushing toward putting 1,000 robots in use in its first phase of the zero-labor project, China National Radio reported. It said the company has already put first 100 robots on the assembly line.
"The 'zero-labor factory' does not mean we will not employ any humans, but what it means is that we will sc...
After 2 volatile days, a return to more calm on Thursday as the S&P 500 fell 0.13% and the NASDAQ 0.17%. The daily Greek drama continues; IMF Managing Director Christine Lagare told a German newspaper that a Greek exit from the euro zone was possible but that this would probably not herald the end of the euro currency. On Wednesday, both U.S. and European equities rallied after Greece said it had stated crafting a “staff level agreement” with its international bailout supervisors. However, European officials rebuked the claims on Thursday, saying there was some way to go before any agreement could be drawn up and that they were surprised by the upbeat sentiment from Greece.
Indexes look much the same as we entered the week.
The tug of war between the bulls and bears has created an unusual situation this year, a historically tight trading range! The chart below reflects that the Dow Jones has traded within a 6.68% high to low trading range this year. That is the 4th tightest trading range through May, in the past 115 years.
CLICK ON CHART TO ENLARGE
The inset table to the right looks at future performance of the Dow following narrow trading ranges through May. As you can see, most of the time the market has ended the year to the upside. Will it be different this time?
Early last week, stocks broke out, with the S&P 500 setting a new high with blue skies overhead. But then the market basically flat-lined for the rest of the week as bulls just couldn’t gather the fuel and conviction to take prices higher. In fact, the technical picture now has turned a bit defensive, at least for the short term, thus joining what has been a neutral-to-defensive tilt to our fundamentals-based Outlook rankings.
In this weekly update, I give my view of the current market environment, offer a technical analysis of the S&P 500 chart, review our weekly fundamentals-based SectorCast rankings of the ten U.S. business sectors, and then offer up some actionable trading ideas, including a sector rotation strategy using ETFs and an enhanced version using top-ranked stocks from the t...
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Understanding the new normal of a business model is key to the success of any company. The managment of companies need to adapt to the changing demand, but first they must recognize what changes are taking place. Big Pharma's business model is changing rapidly, and much like the airline industry, there will be but a handful of pharma companies left at the end of this path.
Most Big Pharma companies have traditionally done everything from research and development (R&D) through to commercialisation themselves. Research was proprietary, and diseases were cherry picked on the back of academic research that was done using NIH grants. This was in the heyday of research, where multiple companies had drugs for the same target (Mevocor, Zocor, Crestor, Lipitor), and could reap the rewards on multiple scales. However, in the c...
Bitcoin, the virtual digital currency, has been called the future of banking, a dangerous fad, and almost everything in between, but we're finally about to get some solid data to help settle the debate.
On Monday, the Nasdaq (NDAQ) stock exchange said it would ...
Chris Kimble likes the idea of shorting the US dollar if it bounces higher. Phil's likes the dollar better long here. These views are not inconsistent, actually, the dollar could bounce and drop again. We'll be watching.
Phil writes: If the Fed begins to tighten OR if Greece defaults OR if China begins to fall apart OR if Japan begins to unwind, then the Dollar could move 10% higher. Without any of those things happening – you still have the Fed pursuing a relatively stronger currency policy than the rest of the G8. So, if anything, I think the pressure should be up, not down.
UNLESS that 95 line does ultimately fail (as opposed to this being bullish consolidation at the prior breakout point), then I'd prefer to sell the UUP Jan $25 puts for $0.85 and buy the Sept $24 call...
Back in December, I wrote a post on my blog where I compared the performances of various ETFs related to the oil industry. I was looking for the best possible proxy to match the moves of oil prices if you didn't want to play with futures. At the time, I concluded that for medium term trades, USO and the leveraged ETFs UCO and SCO were the most promising. Longer term, broader ETFs like OIH and XLE might make better investment if oil prices do recover to more profitable prices since ETF linked to futures like USO, UCO and SCO do suffer from decay. It also seemed that DIG and DUG could be promising if OIH could recover as it should with the price of oil, but that they don't make a good proxy for the price of oil itself.
Kim Parlee interviews Phil on Money Talk. Be sure to watch the replays if you missed the show live on Wednesday night (it was recorded on Monday). As usual, Phil provides an excellent program packed with macro analysis, important lessons and trading ideas. ~ Ilene
The replay is now available on BNN's website. For the three part series, click on the links below.
Part 1 is here (discussing the macro outlook for the markets)
Part 2 is here. (discussing our main trading strategies)
Part 3 is here. (reviewing our pick of th...
This is a non-trading topic, but I wanted to post it during trading hours so as many eyes can see it as possible. Feel free to contact me directly at email@example.com with any questions.
Last fall there was some discussion on the PSW board regarding setting up a YouCaring donation page for a PSW member, Shadowfax. Since then, we have been looking into ways to help get him additional medical services and to pay down his medical debts. After following those leads, we are ready to move ahead with the YouCaring site. (Link is posted below.) Any help you can give will be greatly appreciated; not only to help aid in his medical bill debt, but to also show what a great community this group is.
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