Posts Tagged ‘RNA interference’

Fever to Harness RNA Interference Cools – NYTimes.com

Drugmakers’ Fever for the Power of RNA Interference Has Cooled

By ANDREW POLLACK

When RNA interference first electrified biologists several years ago, pharmaceutical companies rushed to harness what looked like a swift and surefire way to develop new drugs.

Billions of dollars later, however, some of those same companies are now losing their enthusiasm for RNAi, as it is called. And that is raising doubts about how quickly, if at all, the Nobel Prize-winning technique for turning off specific genes will yield the promised bounty of innovative medicines.

The biggest bombshell was dropped in November, when the Swiss pharmaceutical giant Roche said it would end its efforts to develop drugs using RNAi, after it had invested half a billion dollars in the field over four years.

Just last week, as part of a broader research cutback, Pfizer decided to shut down its 100-person unit working on RNAi and related technologies. Abbott Laboratories has also quietly shelved its RNAi drug development work.

“In 2005 and 2006, there was a very sudden buildup of expectation that RNAi was going to cure many diseases in a very short time frame,” said Dr. Johannes Fruehauf, vice president for research at Aura Biosciences, a small company pursuing the field. “Some of the hype, I believe, is going away and a more realistic view is setting in.”

The issue is that while drugs working through the RNAi mechanism can indeed shut off genes, it has been difficult to deliver such drugs to the cells where they are needed. At a time when hard-pressed pharmaceutical companies are already scaling back research expenditures, RNAi is losing out to alternatives that seem closer to producing marketable drugs.

“I have no doubt that at a certain point in time RNAi will make it to the market,” said Klaus Stein, head of therapeutic modalities for Roche. But he added, “When we looked into this, we came to the conclusion that we have opportunities that have higher priorities.”

More here: Fever to Harness RNA Interference Cools – NYTimes.com.


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Zero Hedge

Chevron Facility Goes Offline In Nigeria Following Tweeted Attack By Mysterious Militant Group

Courtesy of ZeroHedge. View original post here.

Submitted by Tyler Durden.

Recently we presented a profile of the latest scourge to haunt Africa's former oil producing powerhouse Nigeria, namely the Niger Delta Avengers, who not only maintained a regularly updated blog following the February launch of their Godaddy-hosted website which even includes a Contact Us section...

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Phil's Favorites

Mish Interview on OilPrice.Com: "Think Beyond Oil And Gold"

Courtesy of Mish.

This past week I was interviewed by James Stafford at Oilprice.com.

We discussed, oil, gold, lithium, other natural resources, global opportunities, and even biotech plays.

Here is the full interview, conducted several days ago.


Think Beyond Oil And Gold: Interview With Mike ‘Mish’ Shedlock

The energy sector was certainly a bargain in January, but no one really knows where oil will be around Christmas. While we may have already seen the bottom, stock prices are not the bargain they were.

There are other p...



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Chart School

Market Recap May 25, 2016

Courtesy of Blain.

Well things just got interesting.  Another significant gap up at the open and strong buying most of the session led to the S&P 500 and NASDAQ both up 0.70%.

Lance Roberts, chief investment strategist at Clarity Financial, said the technical backdrop for stocks has improved, but “we really need to see some follow-through by the end of the week.”

Oil’s gains and indications of a decreasing probability of the U.K. leaving the European Union were “what drove the sentiment change between yesterday and today,” said Andres Jaime, global FX and rates strategist at Barclays.

This day in scary news – the U.S. Defense Department ...



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ValueWalk

Donald Trump will be good for economy But bad for Wall Street: David Rosenberg

By Jacob Wolinsky. Originally published at ValueWalk.

Donald Trump will be good for economy, bad for Wall Street: David Rosenberg

Published on May 25, 2016

Live from the 2016 Strategic Investment Conference

Get the latest updates live from the sold-out 2016 Strategic Investment Conference with John Mauldin, Richard W. Fisher, David Rosenberg, James Grant, Niall Ferguson, George Friedman, Pippa Malmgren, Charles Gave, Neil Howe, and many more. Click go to following link to visit the conference’s live blog:

Some highlights

Hello, everyone who has joined us on the second day of SIC 2016. It’s going to be a long and exciting day. Today, we’ll hear speeches from George Friedman, Lacy Hunt, David Rosenberg, and other well-known financial and political experts. We’ll also do video interviews with each speaker, and all of th...



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Kimble Charting Solutions

S&P 500- Bull Flag potentially in play, breakout about to happen?

Courtesy of Chris Kimble.

Has the S&P 500 formed a “Bullish Flag Pattern” and making an attempt to breakout? Possible. If you are not familiar with the pattern, see more details HERE.

CLICK ON CHART TO ENLARGE

Unless one lives under a rock, you are well aware that that bulls nor bears have anyth...



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Market News

Breaking News And Best Of The Web - May 25

Courtesy of John Rubino.

Central banks likened to pornographers. Greece, believe or not, is still getting bailed out, and China is apparently next. US corporate share buybacks are starting to peter out. Japan lobbies for bigger deficits around the wold. Sprott’s Rick Rule how and why the gold bull market is for real, while precious metals continue correcting. Look for next week’s COT report to be a lot more positive. Pensions are back in the news, and the numbers are as usual very bad. Doug Noland on why the Fed probably can’t raise rates in June — or ever.

Best Of The Web

Gold: Intelligentsia – you’re fired! – 321Gold

...



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OpTrader

Swing trading portfolio - week of May 23rd, 2016

Reminder: OpTrader is available to chat with Members, comments are found below each post.

 

This post is for all our live virtual trade ideas and daily comments. Please click on "comments" below to follow our live discussion. All of our current  trades are listed in the spreadsheet below, with entry price (1/2 in and All in), and exit prices (1/3 out, 2/3 out, and All out).

We also indicate our stop, which is most of the time the "5 day moving average". All trades, unless indicated, are front-month ATM options. 

Please feel free to participate in the discussion and ask any questions you might have about this virtual portfolio, by clicking on the "comments" link right below.

To learn more about the swing trading virtual portfolio (strategy, performance, FAQ, etc.), please click here ...



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Digital Currencies

The Biggest Bitcoin Arbitrage Ever?

Courtesy of Chris at CapitalistExploits

Do you remember when you were growing up and all your friends were allowed Atari game consoles but you weren’t?

Well, I do and the things seemed as foreign to me as Venus. Mostly because the little time I managed to spend on the gaming consoles when my friends weren’t hogging them I found it all a bit silly. I never “got” computer games, and to this day still have poor comprehension of things like Angry Birds.

I suspect that many people around the world view Bitcoin in the same way as I view Angry Birds: with mild amusement and a general lack of understanding as to what the hell all the fuss is about.

I was thinking of this since a buddy of mine recently started ...



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All About Trends

Mid-Day Update

Reminder: Harlan is available to chat with Members, comments are found below each post.

Click here for the full report.




To learn more, sign up for David's free newsletter and receive the free report from All About Trends - "How To Outperform 90% Of Wall Street With Just $500 A Week." Tell David PSW sent you. - Ilene...

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Biotech

This Is Why Biotech Stocks May Explode Again

Reminder: Pharmboy and Ilene are available to chat with Members.

Here's an interesting article from Investor's Business Daily arguing that biotech stocks are beginning to recover from their recent declines, notwithstanding current weakness.

This Is Why Biotech Stocks May Explode Again

By 

Excerpt:

After a three-year bull run that more than quadrupled its value by its peak last July, IBD’s Medical-Biomed/Biotech Industry Group plunged 50% by early February, hurt by backlashes against high drug prices and mergers that seek to lower corporate taxes.

...



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Mapping The Market

About that debate last night

Although we try to stay focused on finding and managing promising trade ideas, the comments in the comment section sometimes take a political turn (for access, try PSW — click here!). So today, Jean Luc writes,

The GOP debate last night was just unreal – are these people running to be president of the US or to lead a college fraternity! Comparing tool size? The only guy that looks semi-sane is Kasich. The other guys are just like 3 jackals right now. 

And something else – if Trump is the candidate, that little Romney speech yesterday is probably already being made into a commercial. And all these little snippets from the debate will also make some nice ads! If you are a conservative, you have to be scared now. 

Phil writes back,

I was expecting them to start throwing poop at each other &n...



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Help One Of Our Own PSW Members

"Hello PSW Members –

This is a non-trading topic, but I wanted to post it during trading hours so as many eyes can see it as possible.  Feel free to contact me directly at jennifersurovy@yahoo.com with any questions.

Last fall there was some discussion on the PSW board regarding setting up a YouCaring donation page for a PSW member, Shadowfax. Since then, we have been looking into ways to help get him additional medical services and to pay down his medical debts.  After following those leads, we are ready to move ahead with the YouCaring site. (Link is posted below.)  Any help you can give will be greatly appreciated; not only to help aid in his medical bill debt, but to also show what a great community this group is.

http://www.youcaring.com/medical-fundraiser/help-get-shadowfax-out-from-the-darkness-of-medical-bills-/126743

Thank you for you time!




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