Posts Tagged ‘sequencing’

Neanderthal DNA Lives On in Modern Humans

Study: Neanderthal DNA Lives On in Modern Humans

By Jennifer Pinkowski, courtesy of TIME 

A decade after scientists first cracked the human genome, researchers announced in the May 7 issue of Science that they have done the same for Neanderthals, the species of hominid that existed from roughly 400,000 to 30,000 years ago, when their closest relatives, early modern humans, may have driven them to extinction.

Led by ancient-DNA expert Svante Pääbo of Germany’s Max Planck Institute for Evolutionary Anthropology, scientists reconstructed about 60% of the Neanderthal genome by analyzing tiny chains of ancient DNA extracted from bone fragments of three female Neanderthals excavated in the late 1970s and early ’80s from a cave in Croatia. The bones are 38,000 to 44,000 years old. 

The genetic information turned up some intriguing findings, indicating, for instance, that at some point after early modern humans migrated out of Africa, they mingled and mated with Neanderthals, possibly in the Middle East or North Africa as much as 80,000 years ago. If that is the case, it occurred significantly earlier than scientists who support the interbreeding hypothesis would have expected.

Comparisons with DNA from modern humans show that some Neanderthal DNA has survived to the present. Moreover, by analyzing ancient DNA alongside modern samples, the team was able to identify a handful of genetic changes that evolved in modern humans sometime after their ancestors and Neanderthals diverged, 440,000 to 270,000 years ago. 

The process of sequencing was painstaking. Among the challenges were eliminating bacterial and fungal DNA, which accounted for 97% of the genetic material in the samples, and guarding against contamination from the researchers, whose DNA might be mistaken for Neanderthals’. Plus, the DNA was so fragmented that the chains were often no longer than 40 or 50 base pairs. "We used half a gram of bones to produce the 3 billion base pairs," Pääbo said in a May 5 press conference. "I really thought until six or seven years ago that it would remain impossible, at least for my lifetime, to sequence the entire genome." New sequencing technologies made it feasible, he said. 

Researchers compared the Neanderthal genome with the genomes of five living people: one San from southern Africa, one Yoruba from West Africa, one Papua New Guinean, one Han Chinese and one French person. Scientists discovered that 1% to 4% of the latter three DNA samples is shared with Neanderthals…
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Zero Hedge

Is This The Bizarre Reason Why Tesla Is Struggling To Ramp Model 3 Production?

Courtesy of ZeroHedge. View original post here.

A little over a week ago, we noted the damning – if unsurprising – report from the Wall Street Journal revealing that Tesla's massive production miss on the Model 3, after only producing a tiny fraction of the 1,500 Model 3 sedans that it promised customers, might have been attributable to the fact that key parts of the cars were still being assembled by hand.

But according to a new report from the WSJ and ...



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Phil's Favorites

The pull of energy markets - and legal challenges - will blunt plans to roll back EPA carbon rules

 

The pull of energy markets – and legal challenges – will blunt plans to roll back EPA carbon rules

Courtesy of Hari OsofskyPennsylvania State University and Hannah WisemanFlorida State University

Grid operators set the prices for energy markets and are structured to take the lowest prices – a disadvantage for coal and nuclear power. CC BY

On Oct. 10, EPA Administrator Scott Pruitt ...



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ValueWalk

Indo-US Obnoxious Stance On CPEC: A Critical Appraisal

By Guest Post. Originally published at ValueWalk.

Since  the beginning of work on China Pakistan Economic Corridor project (CPEC),  India is quite open in opposing this mega Project and now the US has also shown its weight behind India by saying that it too believes the route of corridor passes through a disputed territory — a reference to Northern areas of Pakistan. The statement has come at a time when Foreign Minister Khawaja Asif was in Washington and held series of talks with the US officials to normalize the tense relations. This new stance has started another debate and is undoubtedly going to further damage the bilateral ties, as it is profusely obvious now that US envision a greater role for India in the region. Pakistan and China are wo...



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Chart School

Market Cycle Top?

Courtesy of Declan.

About four years ago I went to a Bloomberg hosted talk on Market Cycles. I have been wracking my brain and Google trying to find the presentation and speaker name (which was available on line) but I thought the talk interesting enough to market in my Google calendar the date for the New Moon in October 2017, which was a focus point convergence of a number of market cycles and potentially a significant market top event (the countdown clock in the sidebar). The years have since ticked by and we are not just a couple of days from the October 2017 New Moon. The market has at least cooperated by sitting at new all-time highs but whether this evolves into a major top remains to be seen. I'm mad with myself that I can't find in my pinboard or delicious bookmarks the link so all I can say is the day will soon be upon us ...

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Insider Scoop

The BLUE And The BOLD; Analyst Suggests Pair Trade Ahead Of Year-End Catalysts

Courtesy of Benzinga.

Related BLUE 30 Stocks Moving In Monday's Mid-Day Session Benzinga's Top Upgrades, Downgrades For October 16, 2017 ...

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Digital Currencies

WTF is the Blockchain?

 

Source: TechiesPad

...

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Mapping The Market

Puts things in perspective

Courtesy of Jean-Luc

Puts things in perspective:

The circles don't look to be to scale much!

...

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Biotech

Circadian rhythm Nobel: what they discovered and why it matters

Reminder: Pharmboy and Ilene are available to chat with Members, comments are found below each post.

 

Circadian rhythm Nobel: what they discovered and why it matters

Courtesy of Sally Ferguson, CQUniversity Australia

Today, the “beautiful mechanism” of the body clock, and the group of cells in our brain where it all happens, have shot to prominence. The 2017 Nobel Prize in Physiology or Medicine has been awarded to Jeffrey C. Hall, Michael Rosbash and Michael W. Young for their work on describing the molecular cogs and wheels inside our biological clock.

In the 18th century an astronomer by the name of Jean Jacques d'Ortuous de Ma...



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Members' Corner

Day of Last Dances

News today has been relentlessly terrible. A horrific mass murder happened last night in Las Vegas. (Our politician's abject failure to address gun control is beyond sickening.) And today, reports that Tom Petty died of a heart attack, followed by reports that Tom Petty is not dead, and now reports confirming that Tom Petty has passed away. 

...

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OpTrader

Swing trading portfolio - week of September 11th, 2017

Reminder: OpTrader is available to chat with Members, comments are found below each post.

 

This post is for all our live virtual trade ideas and daily comments. Please click on "comments" below to follow our live discussion. All of our current  trades are listed in the spreadsheet below, with entry price (1/2 in and All in), and exit prices (1/3 out, 2/3 out, and All out).

We also indicate our stop, which is most of the time the "5 day moving average". All trades, unless indicated, are front-month ATM options. 

Please feel free to participate in the discussion and ask any questions you might have about this virtual portfolio, by clicking on the "comments" link right below.

To learn more about the swing trading virtual portfolio (strategy, performance, FAQ, etc.), please click here ...



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Promotions

NewsWare: Watch Today's Webinar!

 

We have a great guest at today's webinar!

Bill Olsen from NewsWare will be giving us a fun and lively demonstration of the advantages that real-time news provides. NewsWare is a market intelligence tool for news. In today's data driven markets, it is truly beneficial to have a tool that delivers access to the professional sources where you can obtain the facts in real time.

Join our webinar, free, it's open to all. 

Just click here at 1 pm est and join in!

[For more information on NewsWare, click here. For a list of prices: NewsWar...



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Kimble Charting Solutions

Brazil; Waterfall in prices starting? Impact U.S.?

Courtesy of Chris Kimble.

Below looks at the Brazil ETF (EWZ) over the last decade. The rally over the past year has it facing a critical level, from a Power of the Pattern perspective.

CLICK ON CHART TO ENLARGE

EWZ is facing dual resistance at (1), while in a 9-year down trend of lower highs and lower lows. The counter trend rally over the past 17-months has it testing key falling resistance. Did the counter trend reflation rally just end at dual resistance???

If EWZ b...



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All About Trends

Mid-Day Update

Reminder: Harlan is available to chat with Members, comments are found below each post.

Click here for the full report.




To learn more, sign up for David's free newsletter and receive the free report from All About Trends - "How To Outperform 90% Of Wall Street With Just $500 A Week." Tell David PSW sent you. - Ilene...

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