Posts Tagged ‘DNA’

Neanderthal DNA Lives On in Modern Humans

Study: Neanderthal DNA Lives On in Modern Humans

By Jennifer Pinkowski, courtesy of TIME 

A decade after scientists first cracked the human genome, researchers announced in the May 7 issue of Science that they have done the same for Neanderthals, the species of hominid that existed from roughly 400,000 to 30,000 years ago, when their closest relatives, early modern humans, may have driven them to extinction.

Led by ancient-DNA expert Svante Pääbo of Germany’s Max Planck Institute for Evolutionary Anthropology, scientists reconstructed about 60% of the Neanderthal genome by analyzing tiny chains of ancient DNA extracted from bone fragments of three female Neanderthals excavated in the late 1970s and early ’80s from a cave in Croatia. The bones are 38,000 to 44,000 years old. 

The genetic information turned up some intriguing findings, indicating, for instance, that at some point after early modern humans migrated out of Africa, they mingled and mated with Neanderthals, possibly in the Middle East or North Africa as much as 80,000 years ago. If that is the case, it occurred significantly earlier than scientists who support the interbreeding hypothesis would have expected.

Comparisons with DNA from modern humans show that some Neanderthal DNA has survived to the present. Moreover, by analyzing ancient DNA alongside modern samples, the team was able to identify a handful of genetic changes that evolved in modern humans sometime after their ancestors and Neanderthals diverged, 440,000 to 270,000 years ago. 

The process of sequencing was painstaking. Among the challenges were eliminating bacterial and fungal DNA, which accounted for 97% of the genetic material in the samples, and guarding against contamination from the researchers, whose DNA might be mistaken for Neanderthals’. Plus, the DNA was so fragmented that the chains were often no longer than 40 or 50 base pairs. "We used half a gram of bones to produce the 3 billion base pairs," Pääbo said in a May 5 press conference. "I really thought until six or seven years ago that it would remain impossible, at least for my lifetime, to sequence the entire genome." New sequencing technologies made it feasible, he said. 

Researchers compared the Neanderthal genome with the genomes of five living people: one San from southern Africa, one Yoruba from West Africa, one Papua New Guinean, one Han Chinese and one French person. Scientists discovered that 1% to 4% of the latter three DNA samples is shared with Neanderthals…
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Why Genes Aren’t Destiny

Your genes may not be your destiny, but when your grandmother over-ate that one long summer, that was a killer… Fascinating article on epigenetics. – Ilene

Why Genes Aren’t Destiny

TIME photoBy John Cloud, courtesy of TIME

The remote, snow-swept expanses of northern Sweden are an unlikely place to begin a story about cutting-edge genetic science. The kingdom’s northernmost county, Norrbotten, is nearly free of human life; an average of just six people live in each square mile. And yet this tiny population can reveal a lot about how genes work in our everyday lives.

Norrbotten is so isolated that in the 19th century, if the harvest was bad, people starved. The starving years were all the crueler for their unpredictability. For instance, 1800, 1812, 1821, 1836 and 1856 were years of total crop failure and extreme suffering. But in 1801, 1822, 1828, 1844 and 1863, the land spilled forth such abundance that the same people who had gone hungry in previous winters were able to gorge themselves for months.

In the 1980s, Dr. Lars Olov Bygren, a preventive-health specialist who is now at the prestigious Karolinska Institute in Stockholm, began to wonder what long-term effects the feast and famine years might have had on children growing up in Norrbotten in the 19th century — and not just on them but on their kids and grandkids as well. So he drew a random sample of 99 individuals born in the Overkalix parish of Norrbotten in 1905 and used historical records to trace their parents and grandparents back to birth. By analyzing meticulous agricultural records, Bygren and two colleagues determined how much food had been available to the parents and grandparents when they were young.

Around the time he started collecting the data, Bygren had become fascinated with research showing that conditions in the womb could affect your health not only when you were a fetus but well into adulthood. In 1986, for example, the Lancet published the first of two groundbreaking papers showing that if a pregnant woman ate poorly, her child would be at significantly higher than average risk for cardiovascular disease as an adult. Bygren wondered whether that effect could start even before pregnancy: Could parents’ experiences early in their lives somehow change the traits they passed to their offspring?

It was a heretical idea. After all, we have had a long-standing deal with biology:…
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American Express bulls play calendar spread

Today’s tickers: AXP, JNPR, GE, XLF, JPM, WFC, DNA, COP & XOM

AXP – American Express Company – Shares of the global payments and travel company have rallied by 7% to $11.83, an upward move which is likely due to the news that AXP’s fourth quarter earnings were favorably revised yesterday because of an accounting error. Adjustments boosted earnings per share to 21 cents from the previously recorded 15 cents for the quarter, and net income for the year amounted to $2.7 billion up from $2.63 billion originally. Option traders welcomed the unexpected news and established bullish positions on AXP today. One indication of bullishness was the rash of put selling in the March contract. March 10 and 12.5 strikes were heavily sold. Juxtaposed with the near-term bullishness observed is one far-term optimist on AXP, who sees shares doubling by January 2011. In the January 2010 contract at the 20 strike price 10,000 calls were sold for 95 cents each. Using the 20 strike price in January 2011, 10,000 calls were purchased for 1.95 apiece. For this calendar spread to come good, shares would need to nearly double from the current level. We have to think that this spread is already or will be coupled with underlying stock with the risk that the investor is left deficient of shares in the event of a break through $20.00 ahead of expiration.

JNPR – Juniper Networks Inc. – Shares have remained relatively flat today, having fallen just 0.15% to $13.46. The assured and secure Internet Protocol networking solutions company caught our attention due to its high call-to-put ratio which is currently favoring calls 11 times to every single put in play. But, the majority of the calls traded today were sold, indicated an overall bearish picture of the stock. At the March 13 strike price, 3,300 in-the-money calls were sold for 88 cents apiece – perhaps profit taking by investors exiting existing positions at that strike. At the March 14 strike 3,500 calls were shed for 42 cents apiece. The same trend was observed in the April contract where the April 12 strike price had 4,000 calls sold for 1.96, the 13 strike price saw the sale of over 5,100 calls for a premium of 1.28, and the 14 strike had more than 3,600 calls sold for 80 cents per contract. Implied volatility has come off since yesterday reading of 60% to…
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Zero Hedge

Labor Leaders Furious After World Bank Recommends Ditching Minimum Wage

Courtesy of ZeroHedge. View original post here.

Bernie Sanders is preparing to release his version of the "jobs guarantee" that has become a fixture of the UK Labour Party's platform under leader Jeremy Corbyn.

And although his office admits it hasn't carried out a cost analysis for its visionary plan, Sanders says his goal is to guarantee a job (paying $15 an hour) in construction, health-care, education and a handful of other fields, to every American who wants one.

But while the socialist fervor unleashed by Sanders's 2016 primary run shows little sign of abating, a draft report released by the World Bank sh...



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Phil's Favorites

Self-driving cars and humans face inevitable collisions

 

Self-driving cars and humans face inevitable collisions

Self-driving cars and human-driven vehicles are bound to collide as the technology improves. Tempe Police Department via AP

Courtesy of Peter Hancock, University of Central Florida

In 1938, when there were just about one-tenth the number of cars on U.S. roadways as there are today, a brilliant psychologist and a pragmatic engineer joined forces...



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Insider Scoop

Earnings Scheduled For April 25, 2018

Courtesy of Benzinga.

Companies Reporting Before The Bell
  • Thermo Fisher Scientific Inc. (NYSE: TMO) is projected to report quarterly earnings at $2.4 per share on revenue of $5.63 billion.
  • Ford Motor Company (NYSE: F) is expected to report quarterly earnings at $0.41 per share on revenue of $37.16 billion.
  • Twitter, Inc. ...


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Digital Currencies

Hackers Steal $150K After Infiltrating Popular Ethereum Wallet

Courtesy of ZeroHedge. View original post here.

Authored by Marie Huillet via CoinTelegraph

Update: Data from EtherScan shows that over $150k worth of ETH has been stolen in the DNS hack. Starting from 07:17 this morning, 179 inbound transactions totaling 216.06 ETH were sent to ETH address 0x1d50588C0aa11959A5c28831ce3DC5F1D3120d29. At 10:15, the attacker sent 215 ETH to 0x68ca...



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Chart School

The Power of Simple Moving Averages - Crude Oil Warning, Part 3

Courtesy of Read the Ticker.

Many see the large commercial short position with Crude Oil, but what does it mean.

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Sure fundamentals do matter, and so does market timing (entry, stops and exit), here at readtheticker.com we believe a combination of Gann Angles, ...

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Biotech

Why marijuana fans should not see approval for epilepsy drug as a win for weed

Reminder: Pharmboy and Ilene are available to chat with Members, comments are found below each post.

 

Why marijuana fans should not see approval for epilepsy drug as a win for weed

Small vials of CBD, which some believe could be a cure for many ailments. Roxana Gonzalez/Shutterstock.com

Courtesy of Timothy Welty, Drake University

A Food and Drug Administration panel recommended approval of a drug made of cannabidiol on Ap...



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ValueWalk

Buffett At His Best

By csinvesting. Originally published at ValueWalk.

Bear with me as I share a bit of my history that helped me create SkyVu and the Battle Bears games. The University of Nebraska gave me my first job after college. I mostly pushed TV carts around, edited videos for professors or the occasional speaker event. One day, Warren Buffet came to campus to speak to the College of Business. I didn’t think much of this speech at the time but I saved it for some reason. 15 years later, as a founder of my own company, I watch and listen to this particular speech every year to remind myself of the fundamentals and values Mr. Buffett looks for. He’s addressing business students at his alma mater, so I think his style here is a bit more ‘close to home’ than in his other speeches. Hopefully many of you find great value in this video like I have. Sorry for the VHS...



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Kimble Charting Solutions

The Stock Bull Market Stops Here!

 

The Stock Bull Market Stops Here!

Courtesy of Kimble Charting

 

The definition of a bull market or bull trends widely vary. One of the more common criteria for bull markets is determined by the asset being above or below its 200 day moving average.

In my humble opinion, each index above remains in a bull trend, as triple support (200-day moving averages, 2-year rising support lines, and February lows) are still in play ...



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Members' Corner

Cambridge Analytica and the 2016 Election: What you need to know (updated)

 

"If you want to fundamentally reshape society, you first have to break it." ~ Christopher Wylie

[Interview: Cambridge Analytica whistleblower: 'We spent $1m harvesting millions of Facebook profiles' – video]

"You’ve probably heard by now that Cambridge Analytica, which is backed by the borderline-psychotic Mercer family and was formerly chaired by Steve Bannon, had a decisive role in manipulating voters on a one-by-one basis – using their own personal data to push them toward voting ...



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Mapping The Market

The tricks propagandists use to beat science

Via Jean-Luc

How propagandist beat science – they did it for the tobacco industry and now it's in favor of the energy companies:

The tricks propagandists use to beat science

The original tobacco strategy involved several lines of attack. One of these was to fund research that supported the industry and then publish only the results that fit the required narrative. “For instance, in 1954 the TIRC distributed a pamphlet entitled ‘A Scientific Perspective on the Cigarette Controversy’ to nearly 200,000 doctors, journalists, and policy-makers, in which they emphasized favorable research and questioned results supporting the contrary view,” say Weatherall and co, who call this approach biased production.

A second approach promoted independent research that happened to support ...



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OpTrader

Swing trading portfolio - week of September 11th, 2017

Reminder: OpTrader is available to chat with Members, comments are found below each post.

 

This post is for all our live virtual trade ideas and daily comments. Please click on "comments" below to follow our live discussion. All of our current  trades are listed in the spreadsheet below, with entry price (1/2 in and All in), and exit prices (1/3 out, 2/3 out, and All out).

We also indicate our stop, which is most of the time the "5 day moving average". All trades, unless indicated, are front-month ATM options. 

Please feel free to participate in the discussion and ask any questions you might have about this virtual portfolio, by clicking on the "comments" link right below.

To learn more about the swing trading virtual portfolio (strategy, performance, FAQ, etc.), please click here ...



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Promotions

NewsWare: Watch Today's Webinar!

 

We have a great guest at today's webinar!

Bill Olsen from NewsWare will be giving us a fun and lively demonstration of the advantages that real-time news provides. NewsWare is a market intelligence tool for news. In today's data driven markets, it is truly beneficial to have a tool that delivers access to the professional sources where you can obtain the facts in real time.

Join our webinar, free, it's open to all. 

Just click here at 1 pm est and join in!

[For more information on NewsWare, click here. For a list of prices: NewsWar...



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All About Trends

Mid-Day Update

Reminder: Harlan is available to chat with Members, comments are found below each post.

Click here for the full report.




To learn more, sign up for David's free newsletter and receive the free report from All About Trends - "How To Outperform 90% Of Wall Street With Just $500 A Week." Tell David PSW sent you. - Ilene...

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About Phil:

Philip R. Davis is a founder Phil's Stock World, a stock and options trading site that teaches the art of options trading to newcomers and devises advanced strategies for expert traders...

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Ilene is editor and affiliate program coordinator for PSW. She manages the site market shadows, archives, more. Contact Ilene to learn about our affiliate and content sharing programs.

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